Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus
Abstract Objective: This retrospective study aimed to investigate blood-based immune-inflammatory biomarkers (IIBs) in predicting neonatal outcomes in pregnancies with pregestational diabetes mellitus (PGDM).PIV[(neutrophil×platelet×monocyte)/lymphocyte)], SII (neutrophil×platelet/lymphocyte), and...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-05-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100211&lng=en&tlng=en |
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| author | Ayse Cigdem Bayrak Erdem Fadiloglu Haticegul Tuncer Edip Alptug Kir Umutcan Kayikci Ozgur Deren |
| author_facet | Ayse Cigdem Bayrak Erdem Fadiloglu Haticegul Tuncer Edip Alptug Kir Umutcan Kayikci Ozgur Deren |
| author_sort | Ayse Cigdem Bayrak |
| collection | DOAJ |
| description | Abstract Objective: This retrospective study aimed to investigate blood-based immune-inflammatory biomarkers (IIBs) in predicting neonatal outcomes in pregnancies with pregestational diabetes mellitus (PGDM).PIV[(neutrophil×platelet×monocyte)/lymphocyte)], SII (neutrophil×platelet/lymphocyte), and NLR neutrophil/lymphocyte) values were evaluated in all three trimesters, and their correlation with neonatal outcomes was examined. Methods: We included 82 cases of PGDM pregnancies delivered after 32 weeks. Maternal age, gravidity, parity, types of diabetes, and route of delivery were noted. For neonatal outcomes, we recorded gestational age at birth, birth weight percentile, existence of fetal growth restriction, LGA, neonatal intensive care unit (NICU) requirement, Apgar Score <7 at 1, 5, or 10 minutes, need for positive pressure ventilation (PPV), need for mechanical ventilation, hypoglycaemia, hyperbilirubinemia and the need for phototherapy. PIV, SII and NLR values were calculated in each trimester and their association with adverse neonatal outcomes was analyzed. Results: We could not detect any consistent and significant correlation between SII and PIV values and adverse neonatal outcomes for each trimester. There was a correlation between 3rd trimester NLR and adverse neonatal outcomes, including APGAR <7, the requirement for PPV and mechanical ventilation (p=0.056, 0.013 and 0.060, respectively). Conclusion: While SII and PIV values did not consistently correlate with adverse neonatal outcomes throughout each trimester in PGDM pregnancies, 3rd-trimester NLR showed a notable association with the requirement for PPV with statistical significance and with Apgar Score <7 and the requirement for mechanical ventilation without statistical significance. NLR in the third trimester may hold potential as a predictive marker for specific adverse neonatal outcomes in PGDM pregnancies, warranting further investigation. |
| format | Article |
| id | doaj-art-6717cc0e7d5f49c899cbcf0a8dd9fd72 |
| institution | OA Journals |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-6717cc0e7d5f49c899cbcf0a8dd9fd722025-08-20T01:57:01ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-05-014710.61622/rbgo/2025rbgo17Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtusAyse Cigdem Bayrakhttps://orcid.org/0000-0003-1547-3663Erdem Fadilogluhttps://orcid.org/0000-0001-7953-2517Haticegul Tuncerhttps://orcid.org/0009-0001-5217-7188Edip Alptug Kirhttps://orcid.org/0000-0002-2293-3624Umutcan Kayikcihttps://orcid.org/0000-0003-3710-0462Ozgur Derenhttps://orcid.org/0000-0003-4735-2444Abstract Objective: This retrospective study aimed to investigate blood-based immune-inflammatory biomarkers (IIBs) in predicting neonatal outcomes in pregnancies with pregestational diabetes mellitus (PGDM).PIV[(neutrophil×platelet×monocyte)/lymphocyte)], SII (neutrophil×platelet/lymphocyte), and NLR neutrophil/lymphocyte) values were evaluated in all three trimesters, and their correlation with neonatal outcomes was examined. Methods: We included 82 cases of PGDM pregnancies delivered after 32 weeks. Maternal age, gravidity, parity, types of diabetes, and route of delivery were noted. For neonatal outcomes, we recorded gestational age at birth, birth weight percentile, existence of fetal growth restriction, LGA, neonatal intensive care unit (NICU) requirement, Apgar Score <7 at 1, 5, or 10 minutes, need for positive pressure ventilation (PPV), need for mechanical ventilation, hypoglycaemia, hyperbilirubinemia and the need for phototherapy. PIV, SII and NLR values were calculated in each trimester and their association with adverse neonatal outcomes was analyzed. Results: We could not detect any consistent and significant correlation between SII and PIV values and adverse neonatal outcomes for each trimester. There was a correlation between 3rd trimester NLR and adverse neonatal outcomes, including APGAR <7, the requirement for PPV and mechanical ventilation (p=0.056, 0.013 and 0.060, respectively). Conclusion: While SII and PIV values did not consistently correlate with adverse neonatal outcomes throughout each trimester in PGDM pregnancies, 3rd-trimester NLR showed a notable association with the requirement for PPV with statistical significance and with Apgar Score <7 and the requirement for mechanical ventilation without statistical significance. NLR in the third trimester may hold potential as a predictive marker for specific adverse neonatal outcomes in PGDM pregnancies, warranting further investigation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100211&lng=en&tlng=enPregnancy in diabetesPregancyInfant, newbornDiabetes mellitusNeuthrophilsLymphocytesMonocytesRespiration, artificialMaternal ageGestational ageBiomarkersHypoglycemiaIntensive care units, neonatal |
| spellingShingle | Ayse Cigdem Bayrak Erdem Fadiloglu Haticegul Tuncer Edip Alptug Kir Umutcan Kayikci Ozgur Deren Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus Revista Brasileira de Ginecologia e Obstetrícia Pregnancy in diabetes Pregancy Infant, newborn Diabetes mellitus Neuthrophils Lymphocytes Monocytes Respiration, artificial Maternal age Gestational age Biomarkers Hypoglycemia Intensive care units, neonatal |
| title | Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus |
| title_full | Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus |
| title_fullStr | Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus |
| title_full_unstemmed | Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus |
| title_short | Assessıng the predıctıve accuracy of blood-based bıomarkers ın neonatal outcomes for pregestatıonal dıabetes mellıtus |
| title_sort | assessing the predictive accuracy of blood based biomarkers in neonatal outcomes for pregestational diabetes mellitus |
| topic | Pregnancy in diabetes Pregancy Infant, newborn Diabetes mellitus Neuthrophils Lymphocytes Monocytes Respiration, artificial Maternal age Gestational age Biomarkers Hypoglycemia Intensive care units, neonatal |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032025000100211&lng=en&tlng=en |
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