Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/3436943 |
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| author | María Inés Herrera Matilde Otero-Losada Lucas Daniel Udovin Carlos Kusnier Rodolfo Kölliker-Frers Wanderley de Souza Francisco Capani |
| author_facet | María Inés Herrera Matilde Otero-Losada Lucas Daniel Udovin Carlos Kusnier Rodolfo Kölliker-Frers Wanderley de Souza Francisco Capani |
| author_sort | María Inés Herrera |
| collection | DOAJ |
| description | Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model. |
| format | Article |
| id | doaj-art-67171486518e4d32ae445aafd90e23c7 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-67171486518e4d32ae445aafd90e23c72025-08-20T03:35:01ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/34369433436943Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental ModelMaría Inés Herrera0Matilde Otero-Losada1Lucas Daniel Udovin2Carlos Kusnier3Rodolfo Kölliker-Frers4Wanderley de Souza5Francisco Capani6Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Universidad Católica Argentina, Buenos Aires, ArgentinaInstituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, ArgentinaInstituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, ArgentinaInstituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, ArgentinaInstituto de Investigaciones Cardiológicas (ININCA), UBA-CONICET, CABA, Buenos Aires, ArgentinaLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilCentro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Universidad Católica Argentina, Buenos Aires, ArgentinaBirth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model.http://dx.doi.org/10.1155/2017/3436943 |
| spellingShingle | María Inés Herrera Matilde Otero-Losada Lucas Daniel Udovin Carlos Kusnier Rodolfo Kölliker-Frers Wanderley de Souza Francisco Capani Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model Neural Plasticity |
| title | Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model |
| title_full | Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model |
| title_fullStr | Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model |
| title_full_unstemmed | Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model |
| title_short | Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model |
| title_sort | could perinatal asphyxia induce a synaptopathy new highlights from an experimental model |
| url | http://dx.doi.org/10.1155/2017/3436943 |
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