Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study
OBJECTIVE: Investigating the interaction among three interconnected proteins, namely receptor Tyrosine Kinase-2 (Tie-2), the vascular remodeling cytokine Angiopoietin-2 (Ang-2), and the coagulation inhibitor Thrombomodulin (TM), may offer fresh insights into the multifactorial origins of late-onset...
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Medical Network
2024-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1500 |
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| author | Esra Altan Erbilen Fusun Gulizar Varol |
| author_facet | Esra Altan Erbilen Fusun Gulizar Varol |
| author_sort | Esra Altan Erbilen |
| collection | DOAJ |
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OBJECTIVE: Investigating the interaction among three interconnected proteins, namely receptor Tyrosine Kinase-2 (Tie-2), the vascular remodeling cytokine Angiopoietin-2 (Ang-2), and the coagulation inhibitor Thrombomodulin (TM), may offer fresh insights into the multifactorial origins of late-onset fetal growth restriction (LFGR).
STUDY DESIGN: In this prospective cohort study, we assessed the maternal serum concentrations of Tie-2, Ang-2, and TM in pregnancies that developed LFGR (n=30) and a control group (n=59) within the gestational weeks of 32-39 gestational weeks at Trakya University Hospital (January 2021-December 2021). Concentrations were quantified using ELISA, and data analysis was conducted using the SPSS 22.0 Windows software package.
RESULTS: The 75th percentile concentrations of these proteins were significantly lower in cases of LFGR. Among heavy smokers, the risk of LFGR increased by 2.37-fold. A significant correlation was observed between these proteins in both LFGR and healthy pregnancies. However, the sensitivity and specificity of these proteins within the Tie-2, Ang-2, and TM axes were 51%, 56%, 51%, and 45%, 52%, and 50%, respectively. When we examined cases where all three proteins exhibited a consistent trend, LFGRs accounted for 23.33% with reduced levels and 30% with elevated levels, whereas this pattern was observed in 40.67% with reduced levels and 42.37% with elevated levels in healthy pregnancies.
CONCLUSION: Although our study underscores the significance of the intricate interactions between Tie-2, Ang-2, and TM proteins in LFGR pregnancies, it is evident that a more comprehensive investigation is required to make meaningful contributions to the clinical applicability of this subject.
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| format | Article |
| id | doaj-art-6714bcc20edf4ba7b675585f8e046512 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-6714bcc20edf4ba7b675585f8e0465122025-02-11T21:19:01ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182024-12-0130310.21613/GORM.2023.1500Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort StudyEsra Altan Erbilen0Fusun Gulizar Varol1Malatya Training and Research Hospital, Gynecology and Obstetrics PerinatologyTrakya Universitesi Kadın Hastalıkları ve Doğum Anabilim DalıPerinatoloji Bilim Dalı OBJECTIVE: Investigating the interaction among three interconnected proteins, namely receptor Tyrosine Kinase-2 (Tie-2), the vascular remodeling cytokine Angiopoietin-2 (Ang-2), and the coagulation inhibitor Thrombomodulin (TM), may offer fresh insights into the multifactorial origins of late-onset fetal growth restriction (LFGR). STUDY DESIGN: In this prospective cohort study, we assessed the maternal serum concentrations of Tie-2, Ang-2, and TM in pregnancies that developed LFGR (n=30) and a control group (n=59) within the gestational weeks of 32-39 gestational weeks at Trakya University Hospital (January 2021-December 2021). Concentrations were quantified using ELISA, and data analysis was conducted using the SPSS 22.0 Windows software package. RESULTS: The 75th percentile concentrations of these proteins were significantly lower in cases of LFGR. Among heavy smokers, the risk of LFGR increased by 2.37-fold. A significant correlation was observed between these proteins in both LFGR and healthy pregnancies. However, the sensitivity and specificity of these proteins within the Tie-2, Ang-2, and TM axes were 51%, 56%, 51%, and 45%, 52%, and 50%, respectively. When we examined cases where all three proteins exhibited a consistent trend, LFGRs accounted for 23.33% with reduced levels and 30% with elevated levels, whereas this pattern was observed in 40.67% with reduced levels and 42.37% with elevated levels in healthy pregnancies. CONCLUSION: Although our study underscores the significance of the intricate interactions between Tie-2, Ang-2, and TM proteins in LFGR pregnancies, it is evident that a more comprehensive investigation is required to make meaningful contributions to the clinical applicability of this subject. https://gorm.com.tr/index.php/GORM/article/view/1500Angiopoietin-2 Late-onset fetal growth restriction ThrombomodulinTyrosine kinase-2 |
| spellingShingle | Esra Altan Erbilen Fusun Gulizar Varol Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study Gynecology Obstetrics & Reproductive Medicine Angiopoietin-2 Late-onset fetal growth restriction Thrombomodulin Tyrosine kinase-2 |
| title | Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study |
| title_full | Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study |
| title_fullStr | Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study |
| title_full_unstemmed | Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study |
| title_short | Tyrosine Kinase-2, Angiopoietin-2, and Thrombomodulin Axes in the Late-Onset Fetal Growth Restriction: A Prospective Cohort Study |
| title_sort | tyrosine kinase 2 angiopoietin 2 and thrombomodulin axes in the late onset fetal growth restriction a prospective cohort study |
| topic | Angiopoietin-2 Late-onset fetal growth restriction Thrombomodulin Tyrosine kinase-2 |
| url | https://gorm.com.tr/index.php/GORM/article/view/1500 |
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