Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues

Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues

Abstract Lipid membranes are key to the nanoscale compartmentalization of biological systems, but fluorescent visualization of them in intact tissues, with nanoscale precision, is challenging to do with high labeling density. Here, we report ultrastructural membrane expansion microscopy (umExM), whi...

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Main Authors: Tay Won Shin, Hao Wang, Chi Zhang, Bobae An, Yangning Lu, Elizabeth Zhang, Xiaotang Lu, Emmanouil D. Karagiannis, Jeong Seuk Kang, Amauche Emenari, Panagiotis Symvoulidis, Shoh Asano, Leanne Lin, Emma K. Costa, IMAXT Grand Challenge Consortium, Adam H. Marblestone, Narayanan Kasthuri, Li-Huei Tsai, Edward S. Boyden
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56641-z
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