SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS
Proton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note t...
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| Format: | Article |
| Language: | Russian |
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The Publishing House Medicine and Enlightenment
2024-02-01
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| Series: | Медицина в Кузбассе |
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| Online Access: | https://mednauki.ru/index.php/MK/article/view/1041 |
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| author | Дмитрий Иванович Трухан Сергей Николаевич Филимонов |
| author_facet | Дмитрий Иванович Трухан Сергей Николаевич Филимонов |
| author_sort | Дмитрий Иванович Трухан |
| collection | DOAJ |
| description | Proton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially.
For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the associations between PPIs and a number of diseases/conditions.
We searched the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to 12.01.2023. In this review, we examined the effect of long-term use of PPIs on the respiratory system.
Compared with other side effects, changes in the respiratory system have received less attention, but an increased risk of community-acquired pneumonia with long-term use of PPIs has been recognized as likely. Additional prospective studies are needed to elucidate the cause-and-effect mechanisms of the relationship between PPIs and brocho-obstructive diseases. |
| format | Article |
| id | doaj-art-670a9d983e274b6b9ca7fd7a74c8eba8 |
| institution | DOAJ |
| issn | 1819-0901 2588-0411 |
| language | Russian |
| publishDate | 2024-02-01 |
| publisher | The Publishing House Medicine and Enlightenment |
| record_format | Article |
| series | Медицина в Кузбассе |
| spelling | doaj-art-670a9d983e274b6b9ca7fd7a74c8eba82025-08-20T03:14:42ZrusThe Publishing House Medicine and EnlightenmentМедицина в Кузбассе1819-09012588-04112024-02-01231510895SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANSДмитрий Иванович Трухан0Сергей Николаевич Филимонов1ФГБОУ ВО ОмГМУ Минздрава России, г. ОмскФГБНУ НИИ КПГПЗ, г. НовокузнецкProton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the associations between PPIs and a number of diseases/conditions. We searched the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to 12.01.2023. In this review, we examined the effect of long-term use of PPIs on the respiratory system. Compared with other side effects, changes in the respiratory system have received less attention, but an increased risk of community-acquired pneumonia with long-term use of PPIs has been recognized as likely. Additional prospective studies are needed to elucidate the cause-and-effect mechanisms of the relationship between PPIs and brocho-obstructive diseases.https://mednauki.ru/index.php/MK/article/view/1041ингибиторы протонной помпылекарственная безопасностьпобочные эффектывнебольничная пневмонияновая коронавирусная инфекция (covid-19)бронхиальная астмахроническая обструктивная болезнь легких |
| spellingShingle | Дмитрий Иванович Трухан Сергей Николаевич Филимонов SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS Медицина в Кузбассе ингибиторы протонной помпы лекарственная безопасность побочные эффекты внебольничная пневмония новая коронавирусная инфекция (covid-19) бронхиальная астма хроническая обструктивная болезнь легких |
| title | SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS |
| title_full | SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS |
| title_fullStr | SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS |
| title_full_unstemmed | SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS |
| title_short | SIDE EFFECTS OF PROTON PUMP INHIBITORS DURING LONG TERM USE: FOCUS ON THE RESPIRATORY ORGANS |
| title_sort | side effects of proton pump inhibitors during long term use focus on the respiratory organs |
| topic | ингибиторы протонной помпы лекарственная безопасность побочные эффекты внебольничная пневмония новая коронавирусная инфекция (covid-19) бронхиальная астма хроническая обструктивная болезнь легких |
| url | https://mednauki.ru/index.php/MK/article/view/1041 |
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