Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis
Aim. To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with establis...
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Endocrinology Research Centre
2013-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6268 |
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| author | Ekaterina Alexandrovna Repina Tatiana Mikhailovna Atamanova Yana Stanislavovna Zvereva Yulia Vladimirovna Tishina Sergey Alexandrovich Prokof'ev |
| author_facet | Ekaterina Alexandrovna Repina Tatiana Mikhailovna Atamanova Yana Stanislavovna Zvereva Yulia Vladimirovna Tishina Sergey Alexandrovich Prokof'ev |
| author_sort | Ekaterina Alexandrovna Repina |
| collection | DOAJ |
| description | Aim. To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with established AIT comorbidity or elevation of anti-thyroid autoantibodies (ATA). Patients with isolated T1DM (ATA-negative) formed the second group. HLA-genotyping was performed by multiprimer PCR set for the three following genes: DRB1, DQA1 and DQВ1. Results. Prevalence of alleles DRB1*01, *03(017), *04, *07, *11 and genotypes 01/03, 01/04, 03/04 tends to be higher among patients with AIT comorbidity. The comorbidity group was also characterized by the trend towards higher prevalence of ?marker/marker? and ?marker/non-marker? combinations favouring the former variant. Conversely, ATA-negative patients exhibited trend for higher prevalence of ?non-marker/non-marker? combination. Conclusion. Statistically insignificant difference between HLA II alleles and genotypes in the two studied groups suggests that primary genetic factors are common in these two diseases. Plausibly, genes other than DRB1, DQA1 and DQВ1 determine the localization of the autoimmune process. |
| format | Article |
| id | doaj-art-67052df2df23436ca12c5ce56867da7d |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-67052df2df23436ca12c5ce56867da7d2025-08-20T03:09:04ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-12-01164232710.14341/DM2013423-276219Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditisEkaterina Alexandrovna Repina0Tatiana Mikhailovna Atamanova1Yana Stanislavovna Zvereva2Yulia Vladimirovna Tishina3Sergey Alexandrovich Prokof'ev4Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinological Research Centre, MoscowAim. To compare HLA II allele and genotype frequency distribution in type 1 diabetes mellitus (T1DM) and autoimmune thyroiditis (AIT) with that in isolated T1DM. Materials and Methods. A total of 92 T1DM patients were subdivided into two groups. The first group comprised 54 patients with established AIT comorbidity or elevation of anti-thyroid autoantibodies (ATA). Patients with isolated T1DM (ATA-negative) formed the second group. HLA-genotyping was performed by multiprimer PCR set for the three following genes: DRB1, DQA1 and DQВ1. Results. Prevalence of alleles DRB1*01, *03(017), *04, *07, *11 and genotypes 01/03, 01/04, 03/04 tends to be higher among patients with AIT comorbidity. The comorbidity group was also characterized by the trend towards higher prevalence of ?marker/marker? and ?marker/non-marker? combinations favouring the former variant. Conversely, ATA-negative patients exhibited trend for higher prevalence of ?non-marker/non-marker? combination. Conclusion. Statistically insignificant difference between HLA II alleles and genotypes in the two studied groups suggests that primary genetic factors are common in these two diseases. Plausibly, genes other than DRB1, DQA1 and DQВ1 determine the localization of the autoimmune process.https://www.dia-endojournals.ru/jour/article/view/6268type 1 diabetes mellitusautoimmune thyroiditishla iiallelegenotype |
| spellingShingle | Ekaterina Alexandrovna Repina Tatiana Mikhailovna Atamanova Yana Stanislavovna Zvereva Yulia Vladimirovna Tishina Sergey Alexandrovich Prokof'ev Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis Сахарный диабет type 1 diabetes mellitus autoimmune thyroiditis hla ii allele genotype |
| title | Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis |
| title_full | Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis |
| title_fullStr | Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis |
| title_full_unstemmed | Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis |
| title_short | Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis |
| title_sort | comparative analysis of hla ii allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis |
| topic | type 1 diabetes mellitus autoimmune thyroiditis hla ii allele genotype |
| url | https://www.dia-endojournals.ru/jour/article/view/6268 |
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