Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19
BACKGROUND: TB is a leading infectious cause of death worldwide. The COVID-19 pandemic raised concerns that the burden of TB disease and death would increase due to the synergy between the two conditions. METHODS: We used individual-level data submitted to the WHO Global Clinical Platform for COVID-...
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| Format: | Article |
| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-08-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000008/art00002 |
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| author | M. Bastard D. Falzon S. Bertagnolio R. Silva S.S. Thwin C. Siquiera Boccolini J. Rylance J. Diaz M. Zignol |
| author_facet | M. Bastard D. Falzon S. Bertagnolio R. Silva S.S. Thwin C. Siquiera Boccolini J. Rylance J. Diaz M. Zignol |
| author_sort | M. Bastard |
| collection | DOAJ |
| description | BACKGROUND: TB is a leading infectious cause of death worldwide. The COVID-19 pandemic raised concerns that the burden of TB disease and death would increase due to the synergy between the two conditions. METHODS: We used individual-level data submitted to the WHO Global Clinical Platform for COVID-19 on hospitalised patients to explore associations of TB with mortality using multivariable logistic regression. RESULTS: Data were available from 453,233 persons with COVID-19 and known TB status and mortality outcomes from 62 countries (96% SARS-CoV-2 test-positive). Of these, 48% were male, and the median age was 53 years (IQR 38–67). There were 8,214 cases with current TB reported by 46 countries, mainly from Africa. Of people with current TB, 31.4% were admitted with severe illness, and 24.5% died. Current TB was independently associated with higher mortality when adjusted for age, sex, HIV status, illness severity at hospital admission, and underlying conditions (adjusted RR 1.47, 95% CI 1.35–1.61). CONCLUSION: Current or past TB were independent risk factors for in-hospital mortality regardless of illness severity at admission. Caveats for interpretation include changes during the data collection period (viral variation, vaccination coverage) and opportunistic sampling. However, the platform exemplifies how timely, coordinated global reporting can inform our understanding of health emergencies and the vulnerable populations affected. |
| format | Article |
| id | doaj-art-670155d526204083b703a7b84578efae |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-670155d526204083b703a7b84578efae2025-01-22T12:14:14ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-08-011833834310.5588/ijtldopen.24.02102Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19M. Bastard0D. Falzon1S. Bertagnolio2R. Silva3S.S. Thwin4C. Siquiera Boccolini5J. Rylance6J. Diaz7M. Zignol8Global Tuberculosis Programme,Global Tuberculosis Programme,Department of Antimicrobial Resistance,Department of Sexual and Reproductive Health and Research, andDepartment of Sexual and Reproductive Health and Research, andHealth Emergencies Programme, Department of Country Readiness Strengthening, World Health Organization, Geneva, SwitzerlandHealth Emergencies Programme, Department of Country Readiness Strengthening, World Health Organization, Geneva, SwitzerlandHealth Emergencies Programme, Department of Country Readiness Strengthening, World Health Organization, Geneva, SwitzerlandGlobal Tuberculosis Programme,BACKGROUND: TB is a leading infectious cause of death worldwide. The COVID-19 pandemic raised concerns that the burden of TB disease and death would increase due to the synergy between the two conditions. METHODS: We used individual-level data submitted to the WHO Global Clinical Platform for COVID-19 on hospitalised patients to explore associations of TB with mortality using multivariable logistic regression. RESULTS: Data were available from 453,233 persons with COVID-19 and known TB status and mortality outcomes from 62 countries (96% SARS-CoV-2 test-positive). Of these, 48% were male, and the median age was 53 years (IQR 38–67). There were 8,214 cases with current TB reported by 46 countries, mainly from Africa. Of people with current TB, 31.4% were admitted with severe illness, and 24.5% died. Current TB was independently associated with higher mortality when adjusted for age, sex, HIV status, illness severity at hospital admission, and underlying conditions (adjusted RR 1.47, 95% CI 1.35–1.61). CONCLUSION: Current or past TB were independent risk factors for in-hospital mortality regardless of illness severity at admission. Caveats for interpretation include changes during the data collection period (viral variation, vaccination coverage) and opportunistic sampling. However, the platform exemplifies how timely, coordinated global reporting can inform our understanding of health emergencies and the vulnerable populations affected.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000008/art00002tuberculosiscovid-19sars-cov-2mortalitydisease severityhospitalisationclinical database |
| spellingShingle | M. Bastard D. Falzon S. Bertagnolio R. Silva S.S. Thwin C. Siquiera Boccolini J. Rylance J. Diaz M. Zignol Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 IJTLD Open tuberculosis covid-19 sars-cov-2 mortality disease severity hospitalisation clinical database |
| title | Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 |
| title_full | Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 |
| title_fullStr | Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 |
| title_full_unstemmed | Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 |
| title_short | Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 |
| title_sort | outcomes of people with tb reported to the who global clinical platform of covid 19 |
| topic | tuberculosis covid-19 sars-cov-2 mortality disease severity hospitalisation clinical database |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000008/art00002 |
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