A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents
We examined the frequency of elevated urine albumin concentration (UAC) and its association with metabolic syndrome (MetS) and metabolic markers in 515 nondiabetic Mexican adolescents stratified by family history of diabetes (FHD). UAC was measured in a first morning urine sample and considered elev...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/437079 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558245140496384 |
|---|---|
| author | Aida Jiménez-Corona Antonio Ávila-Hermosillo Robert G. Nelson Guadalupe Ramírez-López |
| author_facet | Aida Jiménez-Corona Antonio Ávila-Hermosillo Robert G. Nelson Guadalupe Ramírez-López |
| author_sort | Aida Jiménez-Corona |
| collection | DOAJ |
| description | We examined the frequency of elevated urine albumin concentration (UAC) and its association with metabolic syndrome (MetS) and metabolic markers in 515 nondiabetic Mexican adolescents stratified by family history of diabetes (FHD). UAC was measured in a first morning urine sample and considered elevated when excretion was ≥20 mg/mL. MetS was defined using International Diabetes Federation criteria. Fasting insulin, insulin resistance, and lipids were evaluated. Multivariate logistic regression was performed. Elevated UAC was present in 12.4% and MetS was present in 8.9% of the adolescents. No association was found between elevated UAC and MetS. Among adolescents with FHD, 18.4% were overweight and 20.7% were obese, whereas, among those without a FHD, 15.9% were overweight and 7.5% were obese. Hyperglycemia was higher in those with elevated UAC than in those without (44.4% versus 5.1%, p=0.003). Hyperglycemia (OR = 9.8, 95% CI 1.6–59.4) and number of MetS components (OR = 4.5, 95% CI 1.5–13.3) were independently associated with elevated UAC. Among female participants, abdominal obesity was associated with elevated UAC (OR = 4.5, 95% CI 1.2–16.9). Conclusion. Elevated UAC was associated neither with MetS nor with any metabolic markers in nondiabetic adolescents. However, FHD modified the association of elevated UAC with hyperglycemia and the number of MetS components. |
| format | Article |
| id | doaj-art-6701394472ed4693aa2d40837a049a99 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-6701394472ed4693aa2d40837a049a992025-02-03T01:32:51ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/437079437079A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican AdolescentsAida Jiménez-Corona0Antonio Ávila-Hermosillo1Robert G. Nelson2Guadalupe Ramírez-López3General Directorate of Epidemiology, Health Secretariat, Francisco P Miranda 177, Colonia Lomas de Plateros, Delegación Álvaro Obregón, 01480 Mexico City, DF, MexicoRegional General Hospital No. 89, Mexican Institute of Social Security, Washington 1988, Colonia Moderna, Sector Juárez, 44150 Guadalajara, JAL, MexicoDiabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix Epidemiology and Clinical Research Branch, 1550 East Indian School Road, Phoenix, AZ 85014, USAAdolescent Epidemiological and Health Services Research Unit, Mexican Institute of Social Security, Avenida Tonalá 121, 45400 Guadalajara, JAL, MexicoWe examined the frequency of elevated urine albumin concentration (UAC) and its association with metabolic syndrome (MetS) and metabolic markers in 515 nondiabetic Mexican adolescents stratified by family history of diabetes (FHD). UAC was measured in a first morning urine sample and considered elevated when excretion was ≥20 mg/mL. MetS was defined using International Diabetes Federation criteria. Fasting insulin, insulin resistance, and lipids were evaluated. Multivariate logistic regression was performed. Elevated UAC was present in 12.4% and MetS was present in 8.9% of the adolescents. No association was found between elevated UAC and MetS. Among adolescents with FHD, 18.4% were overweight and 20.7% were obese, whereas, among those without a FHD, 15.9% were overweight and 7.5% were obese. Hyperglycemia was higher in those with elevated UAC than in those without (44.4% versus 5.1%, p=0.003). Hyperglycemia (OR = 9.8, 95% CI 1.6–59.4) and number of MetS components (OR = 4.5, 95% CI 1.5–13.3) were independently associated with elevated UAC. Among female participants, abdominal obesity was associated with elevated UAC (OR = 4.5, 95% CI 1.2–16.9). Conclusion. Elevated UAC was associated neither with MetS nor with any metabolic markers in nondiabetic adolescents. However, FHD modified the association of elevated UAC with hyperglycemia and the number of MetS components.http://dx.doi.org/10.1155/2015/437079 |
| spellingShingle | Aida Jiménez-Corona Antonio Ávila-Hermosillo Robert G. Nelson Guadalupe Ramírez-López A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents Journal of Diabetes Research |
| title | A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents |
| title_full | A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents |
| title_fullStr | A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents |
| title_full_unstemmed | A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents |
| title_short | A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents |
| title_sort | family history of diabetes modifies the association between elevated urine albumin concentration and hyperglycemia in nondiabetic mexican adolescents |
| url | http://dx.doi.org/10.1155/2015/437079 |
| work_keys_str_mv | AT aidajimenezcorona afamilyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT antonioavilahermosillo afamilyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT robertgnelson afamilyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT guadaluperamirezlopez afamilyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT aidajimenezcorona familyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT antonioavilahermosillo familyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT robertgnelson familyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents AT guadaluperamirezlopez familyhistoryofdiabetesmodifiestheassociationbetweenelevatedurinealbuminconcentrationandhyperglycemiainnondiabeticmexicanadolescents |