Evaluation of Beauvericin’s activity and mode of action against all life stages of L. tropica for cutaneous Leishmaniasis therapy

Evaluation of Beauvericin’s activity and mode of action against all life stages of L. tropica for cutaneous Leishmaniasis therapy

BackgroundLeishmaniasis, particularly its cutaneous form caused by Leishmania tropica, remains a significant global health concern due to the limitations of current treatments, including drug resistance, toxicity, and inconsistent efficacy. This study investigates the potential of Beauvericin (BEA),...

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Bibliographic Details
Main Authors: Lynn Al Samra, Mohamad El Nahas, Ilham Mneimneh, Aia Sinno, Sima Tokajian, Kelven Rahy, Sergio Thoumi, Lazo Ali, Wael Yammine, Charbel Al Khoury
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmaniasis
Leishmania tropica
Beauvericin
drug resistance
RNA-Seq
Galleria mellonella model
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1599766/full
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