Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease

We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years o...

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Main Authors: Weidong Pan, Shin Kwak, Yun Liu, Yan Sun, Zhenglong Fang, Baofeng Qin, Yoshiharu Yamamoto
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.4061/2011/789506
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author Weidong Pan
Shin Kwak
Yun Liu
Yan Sun
Zhenglong Fang
Baofeng Qin
Yoshiharu Yamamoto
author_facet Weidong Pan
Shin Kwak
Yun Liu
Yan Sun
Zhenglong Fang
Baofeng Qin
Yoshiharu Yamamoto
author_sort Weidong Pan
collection DOAJ
description We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 (𝑛=59) or placebo granule (𝑛=56) in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponent α, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and the α values. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use.
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series Parkinson's Disease
spelling doaj-art-6700dedd8ff640ee8b456be7fda14d662025-02-03T01:32:04ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/789506789506Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's DiseaseWeidong Pan0Shin Kwak1Yun Liu2Yan Sun3Zhenglong Fang4Baofeng Qin5Yoshiharu Yamamoto6Department of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Graduate School of Medicinel, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaEducational Physiology Laboratory, Graduate School of Education, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, JapanWe evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 (𝑛=59) or placebo granule (𝑛=56) in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponent α, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and the α values. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use.http://dx.doi.org/10.4061/2011/789506
spellingShingle Weidong Pan
Shin Kwak
Yun Liu
Yan Sun
Zhenglong Fang
Baofeng Qin
Yoshiharu Yamamoto
Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
Parkinson's Disease
title Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
title_full Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
title_fullStr Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
title_full_unstemmed Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
title_short Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
title_sort traditional chinese medicine improves activities of daily living in parkinson s disease
url http://dx.doi.org/10.4061/2011/789506
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