Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis
Materials and methods. The study involved 58 patients with cholelithiasis: 56.9% – with stones and 43.1% – with biliary sludge; women – 60.3%, men – 39.7%, the average age of the examined was 60.5±11.6 years. The asymptomatic course was in 46.6% of patients, and the pain syndrome was registered in 5...
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"Consilium Medicum" Publishing house
2024-12-01
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| Series: | Терапевтический архив |
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| author | Pavel V. Seliverstov Valerii G. Radchenko Olga P. Dudanova Nadezhda A. Larina Irina V. Kurbatova Anastasia А. Shipovskaya |
| author_facet | Pavel V. Seliverstov Valerii G. Radchenko Olga P. Dudanova Nadezhda A. Larina Irina V. Kurbatova Anastasia А. Shipovskaya |
| author_sort | Pavel V. Seliverstov |
| collection | DOAJ |
| description | Materials and methods. The study involved 58 patients with cholelithiasis: 56.9% – with stones and 43.1% – with biliary sludge; women – 60.3%, men – 39.7%, the average age of the examined was 60.5±11.6 years. The asymptomatic course was in 46.6% of patients, and the pain syndrome was registered in 53.4%. The diagnosis was verified based on the results of ultrasound examination of the abdominal organs, the X-ray transparency of the concretions was confirmed by X-ray examination and computed tomography. Single stones were found in 63.6% of the patient and double stones in 36.4% of patients. The size of the concretions was 7.71±4.15 mm (3–15 mm). All patients had from 3 to 5 signs of metabolic syndrome. Patients took UDCA at a dose of 10–13 mg / kg for 6–24 months.
Results. There was a positive clinical picture in most patients. Biliary sludge ceased to be detected in all patients after 3–6 months, concretions less than 5 mm – after 6 months. Larger stones of 5–10 mm completely dissolved after 12 months, in 4 patients with stones of 14–15 mm, after 18–24 months, the concretions decreased to 5–7 mm.
Conclusion. UDCA at a dose of 10–13 mg/kg had a 100-percent effect on the dissolution of biliary sludge after 3–6 months and 79.3% result – with respect to the dissolution of concretions within 12–24 months. In parallel, UDCA demonstrated an anti-inflammatory effect, decreased inflammatory markers and decreased endotoxin levels in the blood, as well as improved glucose and lipid metabolism. |
| format | Article |
| id | doaj-art-66ff720cbfe8404ba8308361b18ccff9 |
| institution | DOAJ |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj-art-66ff720cbfe8404ba8308361b18ccff92025-08-20T03:01:07Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422024-12-0196121206121010.26442/00403660.2024.12.20307678639Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasisPavel V. Seliverstov0https://orcid.org/0000-0001-5623-4226Valerii G. Radchenko1https://orcid.org/0000-0002-2964-9167Olga P. Dudanova2https://orcid.org/0000-0003-2613-5694Nadezhda A. Larina3https://orcid.org/0000-0002-0255-4053Irina V. Kurbatova4https://orcid.org/0000-0001-7620-7065Anastasia А. Shipovskaya5https://orcid.org/0000-0003-3830-6446Kirov Military Medical AcademyKirov Military Medical AcademyPetrozavodsk State UniversityPetrozavodsk State UniversityKarelian Research Center of Russian Academy of SciencesPetrozavodsk State UniversityMaterials and methods. The study involved 58 patients with cholelithiasis: 56.9% – with stones and 43.1% – with biliary sludge; women – 60.3%, men – 39.7%, the average age of the examined was 60.5±11.6 years. The asymptomatic course was in 46.6% of patients, and the pain syndrome was registered in 53.4%. The diagnosis was verified based on the results of ultrasound examination of the abdominal organs, the X-ray transparency of the concretions was confirmed by X-ray examination and computed tomography. Single stones were found in 63.6% of the patient and double stones in 36.4% of patients. The size of the concretions was 7.71±4.15 mm (3–15 mm). All patients had from 3 to 5 signs of metabolic syndrome. Patients took UDCA at a dose of 10–13 mg / kg for 6–24 months. Results. There was a positive clinical picture in most patients. Biliary sludge ceased to be detected in all patients after 3–6 months, concretions less than 5 mm – after 6 months. Larger stones of 5–10 mm completely dissolved after 12 months, in 4 patients with stones of 14–15 mm, after 18–24 months, the concretions decreased to 5–7 mm. Conclusion. UDCA at a dose of 10–13 mg/kg had a 100-percent effect on the dissolution of biliary sludge after 3–6 months and 79.3% result – with respect to the dissolution of concretions within 12–24 months. In parallel, UDCA demonstrated an anti-inflammatory effect, decreased inflammatory markers and decreased endotoxin levels in the blood, as well as improved glucose and lipid metabolism.https://ter-arkhiv.ru/0040-3660/article/viewFile/636848/pdfcholecystolithiasisgallstone diseasebiliary sludgeconcretionoral litholysisursofalk |
| spellingShingle | Pavel V. Seliverstov Valerii G. Radchenko Olga P. Dudanova Nadezhda A. Larina Irina V. Kurbatova Anastasia А. Shipovskaya Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis Терапевтический архив cholecystolithiasis gallstone disease biliary sludge concretion oral litholysis ursofalk |
| title | Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis |
| title_full | Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis |
| title_fullStr | Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis |
| title_full_unstemmed | Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis |
| title_short | Results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis |
| title_sort | results of oral litholysis with ursodeoxycholic acid in a patient with cholesterol cholecystolithiasis |
| topic | cholecystolithiasis gallstone disease biliary sludge concretion oral litholysis ursofalk |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/636848/pdf |
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