Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review
Infection with the hepatitis B virus (HBV) is one of the leading global public health issues. Over 250 million people worldwide have chronic HBV infection, out of which roughly 65 million are women in their reproductive age. The most common route of passing the infection in areas of high endemicity...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.2240 |
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| author | Iulia Baciu Dalila-Ana Domuncu Tiberiu Domuncu AncaMarina Ciobanu Theodor Voiosu Gheorghe Peltecu AncaMaria Panaitescu |
| author_facet | Iulia Baciu Dalila-Ana Domuncu Tiberiu Domuncu AncaMarina Ciobanu Theodor Voiosu Gheorghe Peltecu AncaMaria Panaitescu |
| author_sort | Iulia Baciu |
| collection | DOAJ |
| description | Infection with the hepatitis B virus (HBV) is one of the leading global public health issues. Over 250 million people worldwide have chronic HBV infection, out of which roughly 65 million are women in their reproductive age. The most common route of passing the infection in areas of high endemicity is by mother-to-child transmission (MTCT). In children the infection may still occur despite adequate immunoprophylaxis, however, antiviral medication, such as Tenofovir disoproxil fumarate (TDF), may be helpful in reducing the risk of MTCT. A literature review was conducted concerning TDF’s role in preventing MTCT and its safety in pregnancy. Studies were identified by researching various databases up to 2020 for variations of the following sentence: “Tenofovir disoproxil fumarate and Lamivudine and Telbivudine and Entecavir and pregnancy and transmission and safety and HBV”. Prenatal and perinatal adequate management of maternal HBV infection is of utmost importance, with focus on prevention of MTCT as the key strategy to reduce the global HBV infection burden. This review discusses the most up-to-date evidence from a multidisciplinary perspective of using TDF to reduce MTCT of HBV infection as well as its safety profile for pregnant women. |
| format | Article |
| id | doaj-art-66fe5599df664f9791496810d313a0a9 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-66fe5599df664f9791496810d313a0a92025-08-20T02:23:43ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-02-0148191810.31083/j.ceog.2021.01.2240S0390-6663(21)00038-5Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature reviewIulia Baciu0Dalila-Ana Domuncu1Tiberiu Domuncu2AncaMarina Ciobanu3Theodor Voiosu4Gheorghe Peltecu5AncaMaria Panaitescu6Obstetrics-Gynecology, Filantropia Clinical Hospital, 010082 Bucharest, RomaniaIntensive Care Department, National Institute for Infectious Diseases “Prof. dr. Matei Balș”, 010082 Bucharest, RomaniaDepartment of Nephrology, “Dr. Carol Davila” Clinical Nephrology Hospital, 010082 Bucharest, RomaniaObstetrics-Gynecology, Filantropia Clinical Hospital, 010082 Bucharest, RomaniaDepartment of Gastroneterology, Colentina Hospital, 010082 Bucharest, RomaniaObstetrics-Gynecology, Filantropia Clinical Hospital, 010082 Bucharest, RomaniaObstetrics-Gynecology, Filantropia Clinical Hospital, 010082 Bucharest, RomaniaInfection with the hepatitis B virus (HBV) is one of the leading global public health issues. Over 250 million people worldwide have chronic HBV infection, out of which roughly 65 million are women in their reproductive age. The most common route of passing the infection in areas of high endemicity is by mother-to-child transmission (MTCT). In children the infection may still occur despite adequate immunoprophylaxis, however, antiviral medication, such as Tenofovir disoproxil fumarate (TDF), may be helpful in reducing the risk of MTCT. A literature review was conducted concerning TDF’s role in preventing MTCT and its safety in pregnancy. Studies were identified by researching various databases up to 2020 for variations of the following sentence: “Tenofovir disoproxil fumarate and Lamivudine and Telbivudine and Entecavir and pregnancy and transmission and safety and HBV”. Prenatal and perinatal adequate management of maternal HBV infection is of utmost importance, with focus on prevention of MTCT as the key strategy to reduce the global HBV infection burden. This review discusses the most up-to-date evidence from a multidisciplinary perspective of using TDF to reduce MTCT of HBV infection as well as its safety profile for pregnant women.https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.2240tenofovirhepatitis btransmissionmother to childfetal infectionprevention |
| spellingShingle | Iulia Baciu Dalila-Ana Domuncu Tiberiu Domuncu AncaMarina Ciobanu Theodor Voiosu Gheorghe Peltecu AncaMaria Panaitescu Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review Clinical and Experimental Obstetrics & Gynecology tenofovir hepatitis b transmission mother to child fetal infection prevention |
| title | Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review |
| title_full | Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review |
| title_fullStr | Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review |
| title_full_unstemmed | Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review |
| title_short | Tenofovir disoproxil fumarate for preventing mother-to-child transmission of hepatitis B: a literature review |
| title_sort | tenofovir disoproxil fumarate for preventing mother to child transmission of hepatitis b a literature review |
| topic | tenofovir hepatitis b transmission mother to child fetal infection prevention |
| url | https://www.imrpress.com/journal/CEOG/48/1/10.31083/j.ceog.2021.01.2240 |
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