Phylodynamic assessment of SNP distances from whole genome sequencing for determining Mycobacterium tuberculosis transmission

Phylodynamic assessment of SNP distances from whole genome sequencing for determining Mycobacterium tuberculosis transmission

Abstract The global tuberculosis (TB) epidemic is driven by primary transmission. Pathogen genome sequencing is increasingly used in molecular epidemiology and outbreak investigations. Based on contact tracing and epidemiological links, Single Nucleotide Polymorphism (SNP) cut-offs, ranging from 3 t...

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Main Authors: Bastiaan R. Van der Roest, Martin C. J. Bootsma, Egil A. J. Fischer, Matthias I. Gröschel, Richard M. Anthony, Rina de Zwaan, Mirjam E. E. Kretzschmar, Don Klinkenberg
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Phylodynamic modeling
Whole Genome Sequencing
SNP cut-off assessment
Tuberculosis
Transmission
Online Access:https://doi.org/10.1038/s41598-025-94646-2
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