A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions
Abstract To date, no prospective study has been conducted to compare the safety and effectiveness of endoscopic snare resection with an elastic band (ESR-EB) and endoscopic snare resection with a transparent cap (ESR-C) for treating gastric muscularis propria lesions. We aimed to compare the safety...
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Nature Portfolio
2024-12-01
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| author | Zhaohui Liu Xiangyu Wang Genhua Yang Jiefeng Li Yongsheng Lu Dayong Sun Ruinuan Wu |
| author_facet | Zhaohui Liu Xiangyu Wang Genhua Yang Jiefeng Li Yongsheng Lu Dayong Sun Ruinuan Wu |
| author_sort | Zhaohui Liu |
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| description | Abstract To date, no prospective study has been conducted to compare the safety and effectiveness of endoscopic snare resection with an elastic band (ESR-EB) and endoscopic snare resection with a transparent cap (ESR-C) for treating gastric muscularis propria lesions. We aimed to compare the safety and effectiveness of ESR-EB with those of ESR-C for gastric muscularis propria lesions less than 10 mm in diameter. A total of 64 patients were enrolled prospectively from May 2023 to November 2023 at Shenzhen Hospital of Southern Medical University, the First Affiliated Hospital of Shantou University, and the People’s Hospital of Zhongshan City. The study compared clinical characteristics, tumour features, and surgical outcomes between the two groups. Of 64 patients, 29 underwent ESR-C, and 35 underwent ESR-EB. There were no differences in age, gender, location, tumour size, growth pattern, resection time, histology diagnosis, or follow-up time (P > 0.05). Complete resection was achieved in all the patients. The operation time was significantly greater in the ESR-C group than in the ESR-EB group (41.31 ± 9.87 min vs. 26.26 ± 10.32 min, P = 0.000). In the ESR-C cohort, 21 patients (72.41%) had perforation, and 1 patient (3.45%) had bleeding. In the ESR-EB group, 7 patients (20.00%) had perforation. The complication rate varied significantly between the two groups (P = 0.000). No recurrence or metastasis was observed in either group during the follow-up period. Both ESR-C and ESR-EB achieved a 100% complete resection rate for gastric muscularis propria lesions less than 10 mm in diameter.ESR-EB had the potential to reduce the operation time and lower the occurrence of complications. Chinese Clinical Trial Registry Identifier ChiCTR2300072856. |
| format | Article |
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| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-66fb24cb00124e47aa6b3f4ba81e22db2025-08-20T02:39:40ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-83203-yA multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesionsZhaohui Liu0Xiangyu Wang1Genhua Yang2Jiefeng Li3Yongsheng Lu4Dayong Sun5Ruinuan Wu6Department of Gastroenterology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen UniversityDepartment of Gastroenterology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen UniversityDepartment of Gastroenterology, Shenzhen Hospital of Southern Medical UniversityDepartment of Gastroenterology, Zhongshan City People’s HospitalDepartment of Gastroenterology, The First Affiliated Hospital of Shantou UniversityDepartment of Gastroenterology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen UniversityDepartment of Pathology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen UniversityAbstract To date, no prospective study has been conducted to compare the safety and effectiveness of endoscopic snare resection with an elastic band (ESR-EB) and endoscopic snare resection with a transparent cap (ESR-C) for treating gastric muscularis propria lesions. We aimed to compare the safety and effectiveness of ESR-EB with those of ESR-C for gastric muscularis propria lesions less than 10 mm in diameter. A total of 64 patients were enrolled prospectively from May 2023 to November 2023 at Shenzhen Hospital of Southern Medical University, the First Affiliated Hospital of Shantou University, and the People’s Hospital of Zhongshan City. The study compared clinical characteristics, tumour features, and surgical outcomes between the two groups. Of 64 patients, 29 underwent ESR-C, and 35 underwent ESR-EB. There were no differences in age, gender, location, tumour size, growth pattern, resection time, histology diagnosis, or follow-up time (P > 0.05). Complete resection was achieved in all the patients. The operation time was significantly greater in the ESR-C group than in the ESR-EB group (41.31 ± 9.87 min vs. 26.26 ± 10.32 min, P = 0.000). In the ESR-C cohort, 21 patients (72.41%) had perforation, and 1 patient (3.45%) had bleeding. In the ESR-EB group, 7 patients (20.00%) had perforation. The complication rate varied significantly between the two groups (P = 0.000). No recurrence or metastasis was observed in either group during the follow-up period. Both ESR-C and ESR-EB achieved a 100% complete resection rate for gastric muscularis propria lesions less than 10 mm in diameter.ESR-EB had the potential to reduce the operation time and lower the occurrence of complications. Chinese Clinical Trial Registry Identifier ChiCTR2300072856.https://doi.org/10.1038/s41598-024-83203-yEndoscopic Snare ResectionGastric muscularis propria lesionsMulticentreProspective |
| spellingShingle | Zhaohui Liu Xiangyu Wang Genhua Yang Jiefeng Li Yongsheng Lu Dayong Sun Ruinuan Wu A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions Scientific Reports Endoscopic Snare Resection Gastric muscularis propria lesions Multicentre Prospective |
| title | A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions |
| title_full | A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions |
| title_fullStr | A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions |
| title_full_unstemmed | A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions |
| title_short | A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions |
| title_sort | multicentre prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions |
| topic | Endoscopic Snare Resection Gastric muscularis propria lesions Multicentre Prospective |
| url | https://doi.org/10.1038/s41598-024-83203-y |
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