Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches
The interplay between immune cells and malignant cells represents an essential chapter in the eradication of breast cancer. This widely distributed and diverse form of cancer represents a major threat to women worldwide. The incidence of breast cancer is related to several risk factors, notably gene...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399754/full |
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| author | Oumayma Naji Amina Ghouzlani Soumaya Rafii Rizwan ullah Sadiqi Abdou-samad Kone Zakia Harmak Khalil Choukri Sarah Kandoussi Mehdi Karkouri Abdallah Badou Abdallah Badou |
| author_facet | Oumayma Naji Amina Ghouzlani Soumaya Rafii Rizwan ullah Sadiqi Abdou-samad Kone Zakia Harmak Khalil Choukri Sarah Kandoussi Mehdi Karkouri Abdallah Badou Abdallah Badou |
| author_sort | Oumayma Naji |
| collection | DOAJ |
| description | The interplay between immune cells and malignant cells represents an essential chapter in the eradication of breast cancer. This widely distributed and diverse form of cancer represents a major threat to women worldwide. The incidence of breast cancer is related to several risk factors, notably genetic predisposition and family antecedents. Despite progress in treatment modalities varying from surgery and chemotherapy to radiotherapy and targeted therapies, persistently high rates of recurrence, metastasis, and treatment resistance underscore the urgent need for new therapeutic approaches. Immunotherapy has gained considerable ground in the treatment of breast cancer, as it takes advantage of the complex interactions within the tumor microenvironment. This dynamic interplay between immune and tumor cells has become a key point of focus in immunological research. This study investigates the role of various cancer markers, such as neoantigens and immune regulatory genes, in the diagnosis and treatment of breast tumors. Moreover, it explores the future potential of immune checkpoint inhibitors as therapeutically effective agents, as well as the challenges that prevent their efficacy, in particular tumor-induced immunosuppression and the difficulty of achieving tumor specificity. |
| format | Article |
| id | doaj-art-66f75f9617364335a32da3d2aa83300f |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-66f75f9617364335a32da3d2aa83300f2024-12-11T11:36:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-10-011510.3389/fimmu.2024.13997541399754Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approachesOumayma Naji0Amina Ghouzlani1Soumaya Rafii2Rizwan ullah Sadiqi3Abdou-samad Kone4Zakia Harmak5Khalil Choukri6Sarah Kandoussi7Mehdi Karkouri8Abdallah Badou9Abdallah Badou10Immuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoFaculty of Science and Technology, Middlesex University, London, United KingdomImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoDepartment of Pathological Anatomy, University Hospital Center (CHU) Ibn Rochd and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, MoroccoImmuno-Genetics and Human Pathologies Laboratory (LIGEP), Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, MoroccoMohammed VI Center for Research and Innovation, Rabat and Mohammed VI University for Sciences and Health, Casablanca, MoroccoThe interplay between immune cells and malignant cells represents an essential chapter in the eradication of breast cancer. This widely distributed and diverse form of cancer represents a major threat to women worldwide. The incidence of breast cancer is related to several risk factors, notably genetic predisposition and family antecedents. Despite progress in treatment modalities varying from surgery and chemotherapy to radiotherapy and targeted therapies, persistently high rates of recurrence, metastasis, and treatment resistance underscore the urgent need for new therapeutic approaches. Immunotherapy has gained considerable ground in the treatment of breast cancer, as it takes advantage of the complex interactions within the tumor microenvironment. This dynamic interplay between immune and tumor cells has become a key point of focus in immunological research. This study investigates the role of various cancer markers, such as neoantigens and immune regulatory genes, in the diagnosis and treatment of breast tumors. Moreover, it explores the future potential of immune checkpoint inhibitors as therapeutically effective agents, as well as the challenges that prevent their efficacy, in particular tumor-induced immunosuppression and the difficulty of achieving tumor specificity.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399754/fullbreast cancerimmune microenviromentimmune responsetherapy resistanceimmunotherapy |
| spellingShingle | Oumayma Naji Amina Ghouzlani Soumaya Rafii Rizwan ullah Sadiqi Abdou-samad Kone Zakia Harmak Khalil Choukri Sarah Kandoussi Mehdi Karkouri Abdallah Badou Abdallah Badou Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches Frontiers in Immunology breast cancer immune microenviroment immune response therapy resistance immunotherapy |
| title | Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches |
| title_full | Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches |
| title_fullStr | Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches |
| title_full_unstemmed | Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches |
| title_short | Investigating tumor immunogenicity in breast cancer: deciphering the tumor immune response to enhance therapeutic approaches |
| title_sort | investigating tumor immunogenicity in breast cancer deciphering the tumor immune response to enhance therapeutic approaches |
| topic | breast cancer immune microenviroment immune response therapy resistance immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399754/full |
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