Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potential life-threatening clinical syndrome that results from uncontrolled activation of the immune system. Secondary HLH, more commonly observed in adult patients, is seen in the context of underlying triggering conditions. Epstein-Barr virus...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/491567 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553945059295232 |
|---|---|
| author | Neda Hashemi-Sadraei Pimprapa Vejpongsa Muhamed Baljevic Lei Chen Modupe Idowu |
| author_facet | Neda Hashemi-Sadraei Pimprapa Vejpongsa Muhamed Baljevic Lei Chen Modupe Idowu |
| author_sort | Neda Hashemi-Sadraei |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a rare and potential life-threatening clinical syndrome that results from uncontrolled activation of the immune system. Secondary HLH, more commonly observed in adult patients, is seen in the context of underlying triggering conditions. Epstein-Barr virus (EBV) has been recognized as the leading infectious cause and is associated with a poor outcome. As clinical and laboratory features of HLH could overlap with septic shock syndrome in most patients, the diagnosis of HLH, especially in adults, is the most challenging aspect of the disease that results in delayed recognition and treatment of rapidly progressive multiorgan system failure. We report a case of Hemophagocytic lymphohistiocytosis in a patient who presented with signs of septic shock syndrome and we review the literature on the topic. |
| format | Article |
| id | doaj-art-66f6a7cc969448b281dc5d10fcce852f |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-66f6a7cc969448b281dc5d10fcce852f2025-02-03T05:52:45ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/491567491567Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care SettingNeda Hashemi-Sadraei0Pimprapa Vejpongsa1Muhamed Baljevic2Lei Chen3Modupe Idowu4Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USADivision of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USAHemophagocytic lymphohistiocytosis (HLH) is a rare and potential life-threatening clinical syndrome that results from uncontrolled activation of the immune system. Secondary HLH, more commonly observed in adult patients, is seen in the context of underlying triggering conditions. Epstein-Barr virus (EBV) has been recognized as the leading infectious cause and is associated with a poor outcome. As clinical and laboratory features of HLH could overlap with septic shock syndrome in most patients, the diagnosis of HLH, especially in adults, is the most challenging aspect of the disease that results in delayed recognition and treatment of rapidly progressive multiorgan system failure. We report a case of Hemophagocytic lymphohistiocytosis in a patient who presented with signs of septic shock syndrome and we review the literature on the topic.http://dx.doi.org/10.1155/2015/491567 |
| spellingShingle | Neda Hashemi-Sadraei Pimprapa Vejpongsa Muhamed Baljevic Lei Chen Modupe Idowu Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting Case Reports in Hematology |
| title | Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting |
| title_full | Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting |
| title_fullStr | Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting |
| title_full_unstemmed | Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting |
| title_short | Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis: Hematologic Emergency in the Critical Care Setting |
| title_sort | epstein barr virus related hemophagocytic lymphohistiocytosis hematologic emergency in the critical care setting |
| url | http://dx.doi.org/10.1155/2015/491567 |
| work_keys_str_mv | AT nedahashemisadraei epsteinbarrvirusrelatedhemophagocyticlymphohistiocytosishematologicemergencyinthecriticalcaresetting AT pimprapavejpongsa epsteinbarrvirusrelatedhemophagocyticlymphohistiocytosishematologicemergencyinthecriticalcaresetting AT muhamedbaljevic epsteinbarrvirusrelatedhemophagocyticlymphohistiocytosishematologicemergencyinthecriticalcaresetting AT leichen epsteinbarrvirusrelatedhemophagocyticlymphohistiocytosishematologicemergencyinthecriticalcaresetting AT modupeidowu epsteinbarrvirusrelatedhemophagocyticlymphohistiocytosishematologicemergencyinthecriticalcaresetting |