Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue
Malignant ovarian germ cell tumor is a rare disease, but with current treatment strategies including surgery and platinum based chemotherapy survival is excellent. After treatment, intensive followup is indicated to encounter tumor relapse at an early stage. This case describes a 22-year-old female...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2013/984524 |
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| author | M. Y. V. Homs H. W. R. Schreuder G. N. Jonges P. O. Witteveen |
| author_facet | M. Y. V. Homs H. W. R. Schreuder G. N. Jonges P. O. Witteveen |
| author_sort | M. Y. V. Homs |
| collection | DOAJ |
| description | Malignant ovarian germ cell tumor is a rare disease, but with current treatment strategies including surgery and platinum based chemotherapy survival is excellent. After treatment, intensive followup is indicated to encounter tumor relapse at an early stage. This case describes a 22-year-old female with a history of common variable immune deficiency (CVID) who underwent a resection of a large ovarian germ cell tumor followed by 4 cycles of cisplatin and etoposide resulting in clinical complete remission. During followup, she developed a mass at the umbilicus and ascites. Initially, the cytology of the ascites was interpreted as tumor positive, suspicious of relapse of the disease, but tumor markers remained negative. However, during laparoscopy it turned out to be a mature teratoma, which can develop after chemotherapy, the so called growing teratoma syndrome. In retrospect, the ascites was false positive. This case shows that current diagnostic tools are not sufficient to distinguish between vital tumor and mature teratoma and can be misleading. Tumor biopsy and/or laparoscopic inspection are therefore indicated. |
| format | Article |
| id | doaj-art-66f1d7caeb674d95833ee49a67e96356 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-66f1d7caeb674d95833ee49a67e963562025-08-20T03:35:01ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922013-01-01201310.1155/2013/984524984524Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the IssueM. Y. V. Homs0H. W. R. Schreuder1G. N. Jonges2P. O. Witteveen3Department of Medical Oncology, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The NetherlandsDepartment of Reproductive Medicine and Gynaecology, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The NetherlandsDepartment of Pathology, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The NetherlandsDepartment of Medical Oncology, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The NetherlandsMalignant ovarian germ cell tumor is a rare disease, but with current treatment strategies including surgery and platinum based chemotherapy survival is excellent. After treatment, intensive followup is indicated to encounter tumor relapse at an early stage. This case describes a 22-year-old female with a history of common variable immune deficiency (CVID) who underwent a resection of a large ovarian germ cell tumor followed by 4 cycles of cisplatin and etoposide resulting in clinical complete remission. During followup, she developed a mass at the umbilicus and ascites. Initially, the cytology of the ascites was interpreted as tumor positive, suspicious of relapse of the disease, but tumor markers remained negative. However, during laparoscopy it turned out to be a mature teratoma, which can develop after chemotherapy, the so called growing teratoma syndrome. In retrospect, the ascites was false positive. This case shows that current diagnostic tools are not sufficient to distinguish between vital tumor and mature teratoma and can be misleading. Tumor biopsy and/or laparoscopic inspection are therefore indicated.http://dx.doi.org/10.1155/2013/984524 |
| spellingShingle | M. Y. V. Homs H. W. R. Schreuder G. N. Jonges P. O. Witteveen Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue Case Reports in Obstetrics and Gynecology |
| title | Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue |
| title_full | Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue |
| title_fullStr | Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue |
| title_full_unstemmed | Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue |
| title_short | Clinical and Radiologic Signs of Relapsed Ovarian Germ Cell Tumor: Tissue Is the Issue |
| title_sort | clinical and radiologic signs of relapsed ovarian germ cell tumor tissue is the issue |
| url | http://dx.doi.org/10.1155/2013/984524 |
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