Maternal Immunization: Current Evidence, Progress, and Challenges
Maternal immunization is a key strategy for protecting pregnant individuals and newborns from infectious diseases. This review examines the mechanisms and benefits of maternal immunization, with a focus on transplacental IgG transfer and immune system interactions. We provide an overview of current...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/5/450 |
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| author | Veronica Santilli Mayla Sgrulletti Giorgio Costagliola Alessandra Beni Maria Felicia Mastrototaro Davide Montin Caterina Rizzo Baldassarre Martire Michele Miraglia del Giudice Viviana Moschese |
| author_facet | Veronica Santilli Mayla Sgrulletti Giorgio Costagliola Alessandra Beni Maria Felicia Mastrototaro Davide Montin Caterina Rizzo Baldassarre Martire Michele Miraglia del Giudice Viviana Moschese |
| author_sort | Veronica Santilli |
| collection | DOAJ |
| description | Maternal immunization is a key strategy for protecting pregnant individuals and newborns from infectious diseases. This review examines the mechanisms and benefits of maternal immunization, with a focus on transplacental IgG transfer and immune system interactions. We provide an overview of current recommendations and the safety and efficacy profiles of maternal vaccines, including influenza, tetanus–diphtheria–acellular pertussis (Tdap), respiratory syncytial virus (RSV), COVID-19, and hepatitis B. Additionally, we analyze the barriers to maternal immunization, such as misinformation, vaccine hesitancy, and disparities in healthcare access, while exploring potential strategies to overcome these challenges through targeted educational initiatives, improved provider communication, and policy-driven interventions aimed at increasing vaccine confidence and accessibility. Finally, this review highlights recent innovations and future directions in maternal immunization, including emerging vaccines for Group B Streptococcus and cytomegalovirus. Expanding immunization programs and advancing research on maternal–fetal immunity are essential to optimizing vaccination strategies, improving public health outcomes, and reducing the global burden of infectious diseases. |
| format | Article |
| id | doaj-art-66ef161d31b24607af94ca03acdbae13 |
| institution | OA Journals |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-66ef161d31b24607af94ca03acdbae132025-08-20T01:56:42ZengMDPI AGVaccines2076-393X2025-04-0113545010.3390/vaccines13050450Maternal Immunization: Current Evidence, Progress, and ChallengesVeronica Santilli0Mayla Sgrulletti1Giorgio Costagliola2Alessandra Beni3Maria Felicia Mastrototaro4Davide Montin5Caterina Rizzo6Baldassarre Martire7Michele Miraglia del Giudice8Viviana Moschese9Research Unit of Clinical Immunology and Vaccinology, Academic Department of Pediatrics (DPUO), IRCCS Bambino Gesù Children’s Hospital, 00165 Rome, ItalyPediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Rome Tor Vergata, 00133 Rome, ItalySection of Pediatric Hematologyand Oncology, Azienda Ospedaliero Universitaria Pisana, 56126 Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyPediatrics and Neonatology Unit, Maternal-Infant Department, “Monsignor A.R. Dimiccoli” Hospital, 70051 Barletta, ItalyDivision of Pediatric Immunology and Rheumatology, “Regina Margherita” Children Hospital, 10126 Turin, ItalyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, ItalyPediatrics and Neonatology Unit, Maternal-Infant Department, “Monsignor A.R. Dimiccoli” Hospital, 70051 Barletta, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 81100 Naples, ItalyPediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Rome Tor Vergata, 00133 Rome, ItalyMaternal immunization is a key strategy for protecting pregnant individuals and newborns from infectious diseases. This review examines the mechanisms and benefits of maternal immunization, with a focus on transplacental IgG transfer and immune system interactions. We provide an overview of current recommendations and the safety and efficacy profiles of maternal vaccines, including influenza, tetanus–diphtheria–acellular pertussis (Tdap), respiratory syncytial virus (RSV), COVID-19, and hepatitis B. Additionally, we analyze the barriers to maternal immunization, such as misinformation, vaccine hesitancy, and disparities in healthcare access, while exploring potential strategies to overcome these challenges through targeted educational initiatives, improved provider communication, and policy-driven interventions aimed at increasing vaccine confidence and accessibility. Finally, this review highlights recent innovations and future directions in maternal immunization, including emerging vaccines for Group B Streptococcus and cytomegalovirus. Expanding immunization programs and advancing research on maternal–fetal immunity are essential to optimizing vaccination strategies, improving public health outcomes, and reducing the global burden of infectious diseases.https://www.mdpi.com/2076-393X/13/5/450immunizationmaternalinfluenzapertussishepatitis BCOVID-19 |
| spellingShingle | Veronica Santilli Mayla Sgrulletti Giorgio Costagliola Alessandra Beni Maria Felicia Mastrototaro Davide Montin Caterina Rizzo Baldassarre Martire Michele Miraglia del Giudice Viviana Moschese Maternal Immunization: Current Evidence, Progress, and Challenges Vaccines immunization maternal influenza pertussis hepatitis B COVID-19 |
| title | Maternal Immunization: Current Evidence, Progress, and Challenges |
| title_full | Maternal Immunization: Current Evidence, Progress, and Challenges |
| title_fullStr | Maternal Immunization: Current Evidence, Progress, and Challenges |
| title_full_unstemmed | Maternal Immunization: Current Evidence, Progress, and Challenges |
| title_short | Maternal Immunization: Current Evidence, Progress, and Challenges |
| title_sort | maternal immunization current evidence progress and challenges |
| topic | immunization maternal influenza pertussis hepatitis B COVID-19 |
| url | https://www.mdpi.com/2076-393X/13/5/450 |
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