Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda
The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfectio...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3741294 |
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| author | Joseph Baruch Baluku Sylvia Nassozi Brian Gyagenda Margret Namanda Irene Andia-Biraro William Worodria Pauline Byakika-Kibwika |
| author_facet | Joseph Baruch Baluku Sylvia Nassozi Brian Gyagenda Margret Namanda Irene Andia-Biraro William Worodria Pauline Byakika-Kibwika |
| author_sort | Joseph Baruch Baluku |
| collection | DOAJ |
| description | The prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted. |
| format | Article |
| id | doaj-art-66ed920f8d1d48648996ba15263c56c8 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-66ed920f8d1d48648996ba15263c56c82025-02-03T05:46:30ZengWileyJournal of Tropical Medicine1687-96861687-96942019-01-01201910.1155/2019/37412943741294Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in UgandaJoseph Baruch Baluku0Sylvia Nassozi1Brian Gyagenda2Margret Namanda3Irene Andia-Biraro4William Worodria5Pauline Byakika-Kibwika6Mulago National Referral Hospital, Pulmonology Division, P.O. Box 7051 Kampala, UgandaMulago National Referral Hospital, Pulmonology Division, P.O. Box 7051 Kampala, UgandaMulago National Referral Hospital, Pulmonology Division, P.O. Box 7051 Kampala, UgandaMulago National Referral Hospital, Pulmonology Division, P.O. Box 7051 Kampala, UgandaMakerere University College of Health Sciences, Department of Internal Medicine, P.O. Box 7272 Kampala, UgandaMulago National Referral Hospital, Pulmonology Division, P.O. Box 7051 Kampala, UgandaMakerere University College of Health Sciences, Department of Internal Medicine, P.O. Box 7272 Kampala, UgandaThe prevalence of malaria and tuberculosis (TB) coinfection is not well established in countries that are highly burdened for both diseases. Malaria could impair TB containment and increase mortality of TB patients. The objective of this study was to determine the prevalence of malaria/TB coinfection among bacteriologically confirmed adult TB patients at a national TB treatment centre in Uganda. Using a cross-sectional study design we enrolled 363 bacteriologically confirmed adult TB patients, and data on demographics and medical history was collected. Blood samples were tested for malaria blood smear, rapid malaria diagnostic test (RDT), complete blood count, haematological film analysis, HIV serology, and CD4+ and CD8+ cell counts. Malaria was defined as either a positive blood smear or RDT. The study participants were mostly male (61.4%), with a median age of 31 (interquartile range, IQR: 25-39) years, and 35.8% were HIV positive. The prevalence of malaria was 2.2% (8/363) on the overall and 5% (3/58) among participants with rifampicin resistance. A triple infection of HIV, malaria, and rifampicin resistant TB was observed in 3 participants. The prevalence of malaria among TB patients is low, and further evaluation of the epidemiological, clinical, and immunological interaction of the two diseases is warranted.http://dx.doi.org/10.1155/2019/3741294 |
| spellingShingle | Joseph Baruch Baluku Sylvia Nassozi Brian Gyagenda Margret Namanda Irene Andia-Biraro William Worodria Pauline Byakika-Kibwika Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda Journal of Tropical Medicine |
| title | Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda |
| title_full | Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda |
| title_fullStr | Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda |
| title_full_unstemmed | Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda |
| title_short | Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda |
| title_sort | prevalence of malaria and tb coinfection at a national tuberculosis treatment centre in uganda |
| url | http://dx.doi.org/10.1155/2019/3741294 |
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