Systematic Review: Adverse Events of Fecal Microbiota Transplantation.
<h4>Background</h4>Fecal microbiota transplantation (FMT) is a microbiota-based therapy that shows therapeutic potential in recurrent or refractory Clostridium difficile infections and other intestinal or extra-intestinal disorders. Nonetheless, adverse events (AEs) remain a major challe...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0161174 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850108618982031360 |
|---|---|
| author | Sinan Wang Mengque Xu Weiqiang Wang Xiaocang Cao Meiyu Piao Samiullah Khan Fang Yan Hailong Cao Bangmao Wang |
| author_facet | Sinan Wang Mengque Xu Weiqiang Wang Xiaocang Cao Meiyu Piao Samiullah Khan Fang Yan Hailong Cao Bangmao Wang |
| author_sort | Sinan Wang |
| collection | DOAJ |
| description | <h4>Background</h4>Fecal microbiota transplantation (FMT) is a microbiota-based therapy that shows therapeutic potential in recurrent or refractory Clostridium difficile infections and other intestinal or extra-intestinal disorders. Nonetheless, adverse events (AEs) remain a major challenge in the application of FMT.<h4>Aim</h4>To review the AEs of FMT and to address the concerns of safety during the procedure.<h4>Methods</h4>Publications were retrieved in the databases of Medline, Embase and Cochrane Library. AEs were classified according to their causality with FMT or their severity.<h4>Results</h4>A total of 7562 original articles about FMT were identified in this study, 50 of them fulfilled the inclusion criteria. Totally 78 kinds of AEs were revealed enrolled in these 50 selected publications. The total incidence rate of AEs was 28.5%. Among the 42 publications, 5 kinds were definitely and 38 kinds were probably related to FMT. The commonest FMT-attributable AE was abdominal discomfort, which was reported in 19 publications. For upper gastrointestinal routes of FMT, 43.6% (89/204) patients were compromised by FMT-attributable AE, while the incidence dropped to 17.7% (76/430) for lower gastrointestinal routes. In contrast, the incidences of serious adverse events (SAEs) were 2.0% (4/196) and 6.1% (40/659) for upper and lower gastrointestinal routes, respectively. A total of 44 kinds of SAEs occurred in 9.2% patients, including death (3.5%, 38/1089), infection (2.5%, 27/1089), relapse of inflammatory bowel diseases (0.6%, 7/1089) and Clostridium difficile infection (0.9%, 10/1089).<h4>Conclusion</h4>Consequently, both AEs and SAEs are not rare and should be carefully monitored throughout FMT. However, high quality randomized controlled trials are still needed for the more definite incidence of AEs of FMT. |
| format | Article |
| id | doaj-art-66ea858129404b50a6d3e229957b5aea |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-66ea858129404b50a6d3e229957b5aea2025-08-20T02:38:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e016117410.1371/journal.pone.0161174Systematic Review: Adverse Events of Fecal Microbiota Transplantation.Sinan WangMengque XuWeiqiang WangXiaocang CaoMeiyu PiaoSamiullah KhanFang YanHailong CaoBangmao Wang<h4>Background</h4>Fecal microbiota transplantation (FMT) is a microbiota-based therapy that shows therapeutic potential in recurrent or refractory Clostridium difficile infections and other intestinal or extra-intestinal disorders. Nonetheless, adverse events (AEs) remain a major challenge in the application of FMT.<h4>Aim</h4>To review the AEs of FMT and to address the concerns of safety during the procedure.<h4>Methods</h4>Publications were retrieved in the databases of Medline, Embase and Cochrane Library. AEs were classified according to their causality with FMT or their severity.<h4>Results</h4>A total of 7562 original articles about FMT were identified in this study, 50 of them fulfilled the inclusion criteria. Totally 78 kinds of AEs were revealed enrolled in these 50 selected publications. The total incidence rate of AEs was 28.5%. Among the 42 publications, 5 kinds were definitely and 38 kinds were probably related to FMT. The commonest FMT-attributable AE was abdominal discomfort, which was reported in 19 publications. For upper gastrointestinal routes of FMT, 43.6% (89/204) patients were compromised by FMT-attributable AE, while the incidence dropped to 17.7% (76/430) for lower gastrointestinal routes. In contrast, the incidences of serious adverse events (SAEs) were 2.0% (4/196) and 6.1% (40/659) for upper and lower gastrointestinal routes, respectively. A total of 44 kinds of SAEs occurred in 9.2% patients, including death (3.5%, 38/1089), infection (2.5%, 27/1089), relapse of inflammatory bowel diseases (0.6%, 7/1089) and Clostridium difficile infection (0.9%, 10/1089).<h4>Conclusion</h4>Consequently, both AEs and SAEs are not rare and should be carefully monitored throughout FMT. However, high quality randomized controlled trials are still needed for the more definite incidence of AEs of FMT.https://doi.org/10.1371/journal.pone.0161174 |
| spellingShingle | Sinan Wang Mengque Xu Weiqiang Wang Xiaocang Cao Meiyu Piao Samiullah Khan Fang Yan Hailong Cao Bangmao Wang Systematic Review: Adverse Events of Fecal Microbiota Transplantation. PLoS ONE |
| title | Systematic Review: Adverse Events of Fecal Microbiota Transplantation. |
| title_full | Systematic Review: Adverse Events of Fecal Microbiota Transplantation. |
| title_fullStr | Systematic Review: Adverse Events of Fecal Microbiota Transplantation. |
| title_full_unstemmed | Systematic Review: Adverse Events of Fecal Microbiota Transplantation. |
| title_short | Systematic Review: Adverse Events of Fecal Microbiota Transplantation. |
| title_sort | systematic review adverse events of fecal microbiota transplantation |
| url | https://doi.org/10.1371/journal.pone.0161174 |
| work_keys_str_mv | AT sinanwang systematicreviewadverseeventsoffecalmicrobiotatransplantation AT mengquexu systematicreviewadverseeventsoffecalmicrobiotatransplantation AT weiqiangwang systematicreviewadverseeventsoffecalmicrobiotatransplantation AT xiaocangcao systematicreviewadverseeventsoffecalmicrobiotatransplantation AT meiyupiao systematicreviewadverseeventsoffecalmicrobiotatransplantation AT samiullahkhan systematicreviewadverseeventsoffecalmicrobiotatransplantation AT fangyan systematicreviewadverseeventsoffecalmicrobiotatransplantation AT hailongcao systematicreviewadverseeventsoffecalmicrobiotatransplantation AT bangmaowang systematicreviewadverseeventsoffecalmicrobiotatransplantation |