The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy

Cancer cachexia, a multifactorial metabolic syndrome impacts 50–80 % cancer patients, is mainly characterized by skeletal muscle atrophy. In this study, we demonstrated that the thousand-and-one amino acid kinase 1 (TAOK1) was activated in both C2C12 myotubes treated with simulated cancer cachexia i...

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Bibliographic Details
Main Authors: Ruiqin Zhang, Nan Li, Ke Yu, Qiongsen Wang, Meng Fan, Xiongwen Zhang, Xuan Liu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
Cancer cachexia
Muscle atrophy
TAOK1
C2C12 myotubes
Tumor-bearing mice
MAPK pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001884
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