S100A4 contributes to colorectal carcinoma aggressive behavior and to chemoradiotherapy resistance in locally advanced rectal carcinoma

S100A4 contributes to colorectal carcinoma aggressive behavior and to chemoradiotherapy resistance in locally advanced rectal carcinoma

Abstract To investigate the functional role of S100A4 in advanced colorectal carcinoma (Ad-CRC) and locally advanced rectal carcinoma (LAd-RC) receiving neoadjuvant chemoradiotherapy (NCRT). We analyzed histopathological and immunohistochemical sections from 150 patients with Ad-CRC and 177 LAd-RC p...

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Main Authors: Yohei Harada, Sayako Ikeda, Yuna Kawabe, Yasuko Oguri, Miki Hashimura, Ako Yokoi, Akiko Sida, Naomi Fukagawa, Misato Hayashi, Mototsugu Ono, Chika Kusano, Hiroyuki Takahashi, Makoto Saegusa
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
S100A4
p53
Apoptosis
Colorectal carcinoma
Neoadjuvant chemoradiotherapy
Online Access:https://doi.org/10.1038/s41598-024-82814-9
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