Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study
<b>Background/Objectives:</b> Cardiovascular complications are a leading cause of premature mortality in patients with acromegaly. Copeptin (CPP) correlates strongly with plasma osmolality and is regulated by non-osmotic stimuli involved in the pathophysiology of cardiovascular disease....
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/3/666 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850089937880219648 |
|---|---|
| author | Martyna Strzelec Eliza Kubicka Justyna Kuliczkowska-Płaksej Katarzyna Kolačkov Łucja Janek Marek Bolanowski Aleksandra Jawiarczyk-Przybyłowska |
| author_facet | Martyna Strzelec Eliza Kubicka Justyna Kuliczkowska-Płaksej Katarzyna Kolačkov Łucja Janek Marek Bolanowski Aleksandra Jawiarczyk-Przybyłowska |
| author_sort | Martyna Strzelec |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Cardiovascular complications are a leading cause of premature mortality in patients with acromegaly. Copeptin (CPP) correlates strongly with plasma osmolality and is regulated by non-osmotic stimuli involved in the pathophysiology of cardiovascular disease. Mid-regional proadrenomedullin (MR-proADM), synthesized mainly in the adrenal medulla, vascular endothelial cells, and the heart, has vasodilatory effects. The study aimed to assess two cardiovascular biomarkers (CPP and MR-proADM) in acromegaly patients in relation to disease activity and compare findings with a control group. <b>Methods:</b> The study examined CPP and MR-proADM levels alongside hormonal and biochemical parameters and cardiovascular and metabolic disease prevalence in 53 acromegaly patients and 26 controls. <b>Results:</b> No significant differences in CPP or MR-proADM concentrations were observed between the two groups. However, a positive correlation occurred between growth hormone (GH) and CPP concentrations, and there was a negative correlation between fasting glucose and CPP concentrations in acromegaly patients. The study also found a positive correlation between low-density lipoprotein (LDL) cholesterol and MR-proADM concentrations and between high-density lipoprotein (HDL) cholesterol and MR-proADM levels in the study group. Moreover, atherogenic dyslipidemia was significantly more common in the active form of acromegaly and pituitary macroadenoma patients than in the control group. Acromegaly patients had significantly higher fasting glucose and fasting insulin levels compared to controls, and the homeostasis model assessment of the insulin resistance (HOMA-IR) index was significantly lower in the study group than in the controls. <b>Conclusions:</b> Neither CPP or MR-proADM are significant diagnostic or monitoring indicators of cardiovascular or metabolic complications in acromegaly. |
| format | Article |
| id | doaj-art-66d4e22ef4da4916a3044ed32dd17528 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-66d4e22ef4da4916a3044ed32dd175282025-08-20T02:42:39ZengMDPI AGBiomedicines2227-90592025-03-0113366610.3390/biomedicines13030666Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary StudyMartyna Strzelec0Eliza Kubicka1Justyna Kuliczkowska-Płaksej2Katarzyna Kolačkov3Łucja Janek4Marek Bolanowski5Aleksandra Jawiarczyk-Przybyłowska6Department and Clinic of Endocrinology and Internal Medicine, Wroclaw Medical University, Wybrzeże Pasteura 4, 50-367 Wroclaw, PolandDepartment of Nuclear Medicine, Tadeusz Marciniak Lower Silesia Specialist Hospital-Centre for Medical Emergency, 54-049 Wroclaw, PolandDepartment and Clinic of Endocrinology and Internal Medicine, Wroclaw Medical University, Wybrzeże Pasteura 4, 50-367 Wroclaw, PolandDepartment and Clinic of Endocrinology and Internal Medicine, Wroclaw Medical University, Wybrzeże Pasteura 4, 50-367 Wroclaw, PolandStatistical Analysis Centre, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment and Clinic of Endocrinology and Internal Medicine, Wroclaw Medical University, Wybrzeże Pasteura 4, 50-367 Wroclaw, PolandDepartment and Clinic of Endocrinology and Internal Medicine, Wroclaw Medical University, Wybrzeże Pasteura 4, 50-367 Wroclaw, Poland<b>Background/Objectives:</b> Cardiovascular complications are a leading cause of premature mortality in patients with acromegaly. Copeptin (CPP) correlates strongly with plasma osmolality and is regulated by non-osmotic stimuli involved in the pathophysiology of cardiovascular disease. Mid-regional proadrenomedullin (MR-proADM), synthesized mainly in the adrenal medulla, vascular endothelial cells, and the heart, has vasodilatory effects. The study aimed to assess two cardiovascular biomarkers (CPP and MR-proADM) in acromegaly patients in relation to disease activity and compare findings with a control group. <b>Methods:</b> The study examined CPP and MR-proADM levels alongside hormonal and biochemical parameters and cardiovascular and metabolic disease prevalence in 53 acromegaly patients and 26 controls. <b>Results:</b> No significant differences in CPP or MR-proADM concentrations were observed between the two groups. However, a positive correlation occurred between growth hormone (GH) and CPP concentrations, and there was a negative correlation between fasting glucose and CPP concentrations in acromegaly patients. The study also found a positive correlation between low-density lipoprotein (LDL) cholesterol and MR-proADM concentrations and between high-density lipoprotein (HDL) cholesterol and MR-proADM levels in the study group. Moreover, atherogenic dyslipidemia was significantly more common in the active form of acromegaly and pituitary macroadenoma patients than in the control group. Acromegaly patients had significantly higher fasting glucose and fasting insulin levels compared to controls, and the homeostasis model assessment of the insulin resistance (HOMA-IR) index was significantly lower in the study group than in the controls. <b>Conclusions:</b> Neither CPP or MR-proADM are significant diagnostic or monitoring indicators of cardiovascular or metabolic complications in acromegaly.https://www.mdpi.com/2227-9059/13/3/666acromegalycardiovascular diseasescopeptinmid-regional proadrenomedullin |
| spellingShingle | Martyna Strzelec Eliza Kubicka Justyna Kuliczkowska-Płaksej Katarzyna Kolačkov Łucja Janek Marek Bolanowski Aleksandra Jawiarczyk-Przybyłowska Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study Biomedicines acromegaly cardiovascular diseases copeptin mid-regional proadrenomedullin |
| title | Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study |
| title_full | Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study |
| title_fullStr | Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study |
| title_full_unstemmed | Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study |
| title_short | Copeptin and Mid-Regional Proadrenomedullin Are Not Useful Biomarkers of Cardiometabolic Disease in Patients with Acromegaly—A Preliminary Study |
| title_sort | copeptin and mid regional proadrenomedullin are not useful biomarkers of cardiometabolic disease in patients with acromegaly a preliminary study |
| topic | acromegaly cardiovascular diseases copeptin mid-regional proadrenomedullin |
| url | https://www.mdpi.com/2227-9059/13/3/666 |
| work_keys_str_mv | AT martynastrzelec copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy AT elizakubicka copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy AT justynakuliczkowskapłaksej copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy AT katarzynakolackov copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy AT łucjajanek copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy AT marekbolanowski copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy AT aleksandrajawiarczykprzybyłowska copeptinandmidregionalproadrenomedullinarenotusefulbiomarkersofcardiometabolicdiseaseinpatientswithacromegalyapreliminarystudy |