Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol
Introduction Nerve sheath tumours arise from both the central and peripheral nervous systems. In particular, cases of spinal or paraspinal origins are scarce and poorly covered in the literature. This systematic review aims to summarise the body of evidence regarding spinal nerve sheath tumours and...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-10-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/10/e083011.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849720521182150656 |
|---|---|
| author | Erik Edström Adrian Elmi-Terander Victor Gabriel El-Hajj Maria Gharios Omar Ali Mahdi Aman Singh Adnan Fatfat |
| author_facet | Erik Edström Adrian Elmi-Terander Victor Gabriel El-Hajj Maria Gharios Omar Ali Mahdi Aman Singh Adnan Fatfat |
| author_sort | Erik Edström |
| collection | DOAJ |
| description | Introduction Nerve sheath tumours arise from both the central and peripheral nervous systems. In particular, cases of spinal or paraspinal origins are scarce and poorly covered in the literature. This systematic review aims to summarise the body of evidence regarding spinal nerve sheath tumours and assess its quality, to provide the current knowledge on epidemiology, tumour characteristics, diagnostics, treatment strategies and outcomes.Methods and analysis Databases including PubMed, Web of Science and Embase will be searched using keywords such as “spinal”, “nerve sheath”, “neurofibroma”, “schwannoma”, “neurinoma” and “neurilemoma”. The search will be limited to studies published no earlier than 2000 without language restrictions. Case reports, editorials, letters and reviews will be excluded. Reference lists of identified studies will be searched to find possible additional relevant records. Identified studies will be screened for inclusion, by one reviewer at first and then two independent ones in the next step to increase the external validity. The Rayyan platform will be used for the screening and inclusion process. Data extraction within several predetermined areas of interest will proceed. Subjects of interest include epidemiology, histopathology, radiological diagnostics, surgery, complications, non-surgical treatment alternatives, disease outcomes and predictors of outcome, and recurrence rates. On satisfactory amount of homogenous data, a meta-analysis of key outcomes such as recurrence risk or postoperative neurological improvement will be performed. This systematic review will primarily serve as a reference guide to aid in diagnosis and treatment of patients with spinal schwannomas, while also spotlighting the knowledge gaps in the literature to help guide future research initiatives.Ethics and dissemination Ethics approval is not required for the protocol or review as both are based on existing publications. For dissemination, the final manuscript will be submitted to a peer-reviewed journal. |
| format | Article |
| id | doaj-art-66d4a2568ea04c72bdd668a63d4bf319 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-66d4a2568ea04c72bdd668a63d4bf3192025-08-20T03:11:54ZengBMJ Publishing GroupBMJ Open2044-60552024-10-01141010.1136/bmjopen-2023-083011Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocolErik Edström0Adrian Elmi-Terander1Victor Gabriel El-Hajj2Maria Gharios3Omar Ali Mahdi4Aman Singh5Adnan Fatfat61 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden1 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenIntroduction Nerve sheath tumours arise from both the central and peripheral nervous systems. In particular, cases of spinal or paraspinal origins are scarce and poorly covered in the literature. This systematic review aims to summarise the body of evidence regarding spinal nerve sheath tumours and assess its quality, to provide the current knowledge on epidemiology, tumour characteristics, diagnostics, treatment strategies and outcomes.Methods and analysis Databases including PubMed, Web of Science and Embase will be searched using keywords such as “spinal”, “nerve sheath”, “neurofibroma”, “schwannoma”, “neurinoma” and “neurilemoma”. The search will be limited to studies published no earlier than 2000 without language restrictions. Case reports, editorials, letters and reviews will be excluded. Reference lists of identified studies will be searched to find possible additional relevant records. Identified studies will be screened for inclusion, by one reviewer at first and then two independent ones in the next step to increase the external validity. The Rayyan platform will be used for the screening and inclusion process. Data extraction within several predetermined areas of interest will proceed. Subjects of interest include epidemiology, histopathology, radiological diagnostics, surgery, complications, non-surgical treatment alternatives, disease outcomes and predictors of outcome, and recurrence rates. On satisfactory amount of homogenous data, a meta-analysis of key outcomes such as recurrence risk or postoperative neurological improvement will be performed. This systematic review will primarily serve as a reference guide to aid in diagnosis and treatment of patients with spinal schwannomas, while also spotlighting the knowledge gaps in the literature to help guide future research initiatives.Ethics and dissemination Ethics approval is not required for the protocol or review as both are based on existing publications. For dissemination, the final manuscript will be submitted to a peer-reviewed journal.https://bmjopen.bmj.com/content/14/10/e083011.full |
| spellingShingle | Erik Edström Adrian Elmi-Terander Victor Gabriel El-Hajj Maria Gharios Omar Ali Mahdi Aman Singh Adnan Fatfat Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol BMJ Open |
| title | Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol |
| title_full | Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol |
| title_fullStr | Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol |
| title_full_unstemmed | Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol |
| title_short | Epidemiology, tumour characteristics, treatment and outcomes associated with spinal nerve sheath tumours: a systematic review protocol |
| title_sort | epidemiology tumour characteristics treatment and outcomes associated with spinal nerve sheath tumours a systematic review protocol |
| url | https://bmjopen.bmj.com/content/14/10/e083011.full |
| work_keys_str_mv | AT erikedstrom epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol AT adrianelmiterander epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol AT victorgabrielelhajj epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol AT mariagharios epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol AT omaralimahdi epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol AT amansingh epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol AT adnanfatfat epidemiologytumourcharacteristicstreatmentandoutcomesassociatedwithspinalnervesheathtumoursasystematicreviewprotocol |