Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation
Processing emotionally meaningful stimuli and eliciting appropriate valence-specific behavior in response is a critical brain function for survival. Thus, how positive and negative valence are represented in neural circuits and how corresponding neural substrates interact to cooperatively select app...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010224000889 |
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| author | Kenta M. Hagihara Andreas Lüthi |
| author_facet | Kenta M. Hagihara Andreas Lüthi |
| author_sort | Kenta M. Hagihara |
| collection | DOAJ |
| description | Processing emotionally meaningful stimuli and eliciting appropriate valence-specific behavior in response is a critical brain function for survival. Thus, how positive and negative valence are represented in neural circuits and how corresponding neural substrates interact to cooperatively select appropriate behavioral output are fundamental questions. In previous work, we identified that two amygdala intercalated clusters show opposite response selectivity to fear- and anxiety-inducing stimuli – negative valence (Hagihara et al., 2021). Here, we further show that the two clusters also exhibit distinctly different representations of stimuli with positive valence, demonstrating a broader role of the amygdala intercalated system beyond fear and anxiety. Together with the mutually inhibitory connectivity between the two clusters, our findings suggest that they serve as an ideal neural substrate for the integrated processing of valence for the selection of behavioral output. |
| format | Article |
| id | doaj-art-66d3f8b12f524a528c1436777e756c4e |
| institution | OA Journals |
| issn | 0168-0102 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-66d3f8b12f524a528c1436777e756c4e2025-08-20T02:21:07ZengElsevierNeuroscience Research0168-01022024-12-01209283310.1016/j.neures.2024.07.003Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivationKenta M. Hagihara0Andreas Lüthi1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, Switzerland; Corresponding author at: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; University of Basel, Basel, SwitzerlandProcessing emotionally meaningful stimuli and eliciting appropriate valence-specific behavior in response is a critical brain function for survival. Thus, how positive and negative valence are represented in neural circuits and how corresponding neural substrates interact to cooperatively select appropriate behavioral output are fundamental questions. In previous work, we identified that two amygdala intercalated clusters show opposite response selectivity to fear- and anxiety-inducing stimuli – negative valence (Hagihara et al., 2021). Here, we further show that the two clusters also exhibit distinctly different representations of stimuli with positive valence, demonstrating a broader role of the amygdala intercalated system beyond fear and anxiety. Together with the mutually inhibitory connectivity between the two clusters, our findings suggest that they serve as an ideal neural substrate for the integrated processing of valence for the selection of behavioral output.http://www.sciencedirect.com/science/article/pii/S0168010224000889AmygdalaValence processingRewardPunishmentMotivationValence-specific behavior |
| spellingShingle | Kenta M. Hagihara Andreas Lüthi Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation Neuroscience Research Amygdala Valence processing Reward Punishment Motivation Valence-specific behavior |
| title | Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation |
| title_full | Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation |
| title_fullStr | Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation |
| title_full_unstemmed | Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation |
| title_short | Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation |
| title_sort | bidirectional valence coding in amygdala intercalated clusters a neural substrate for the opponent process theory of motivation |
| topic | Amygdala Valence processing Reward Punishment Motivation Valence-specific behavior |
| url | http://www.sciencedirect.com/science/article/pii/S0168010224000889 |
| work_keys_str_mv | AT kentamhagihara bidirectionalvalencecodinginamygdalaintercalatedclustersaneuralsubstratefortheopponentprocesstheoryofmotivation AT andreasluthi bidirectionalvalencecodinginamygdalaintercalatedclustersaneuralsubstratefortheopponentprocesstheoryofmotivation |