Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety

Tricyclic antidepressants, not influencing the P450 3A4 activity, are safe in combination with drugs of other groups used in the treatment of comorbid patients. Azaphen is is one of the agents most widely used in the clinical practice. The in vitro electrochemical analysis showed that pipofezin (aza...

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Bibliographic Details
Main Authors: E. V. Fomin, I. H. Baychorov, E. V. Shih, Zh. M. Sizova
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Series:Антибиотики и Химиотерапия
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Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/499
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