Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety
Tricyclic antidepressants, not influencing the P450 3A4 activity, are safe in combination with drugs of other groups used in the treatment of comorbid patients. Azaphen is is one of the agents most widely used in the clinical practice. The in vitro electrochemical analysis showed that pipofezin (aza...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/499 |
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| author | E. V. Fomin I. H. Baychorov E. V. Shih Zh. M. Sizova |
| author_facet | E. V. Fomin I. H. Baychorov E. V. Shih Zh. M. Sizova |
| author_sort | E. V. Fomin |
| collection | DOAJ |
| description | Tricyclic antidepressants, not influencing the P450 3A4 activity, are safe in combination with drugs of other groups used in the treatment of comorbid patients. Azaphen is is one of the agents most widely used in the clinical practice. The in vitro electrochemical analysis showed that pipofezin (azaphen) was not a substrate, inductor, and/or inhibitor of cytochrome P450 CYP3A4 isoenzymes. The Guzar programme computer modelling and the literature data demonstrated the substrate affinity of pipifezin to CYP1A2. |
| format | Article |
| id | doaj-art-66c9d559bec84f47b9c76efcba54f4ac |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-66c9d559bec84f47b9c76efcba54f4ac2025-08-20T03:42:01ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01587-83439498Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy SafetyE. V. Fomin0I. H. Baychorov1E. V. Shih2Zh. M. Sizova3Scientific Centre for Examination of Medicinal ProductMunicipal Polyclinic No. 2I.M. Sechenov 1st Moscow State Medical UniversityI.M. Sechenov 1st Moscow State Medical UniversityTricyclic antidepressants, not influencing the P450 3A4 activity, are safe in combination with drugs of other groups used in the treatment of comorbid patients. Azaphen is is one of the agents most widely used in the clinical practice. The in vitro electrochemical analysis showed that pipofezin (azaphen) was not a substrate, inductor, and/or inhibitor of cytochrome P450 CYP3A4 isoenzymes. The Guzar programme computer modelling and the literature data demonstrated the substrate affinity of pipifezin to CYP1A2.https://www.antibiotics-chemotherapy.ru/jour/article/view/499drug interactionspipofezinmetabolismsubstratesinducers and inhibitors of cytochrome isoenzymes p4503a4p4501a2electrochemical method |
| spellingShingle | E. V. Fomin I. H. Baychorov E. V. Shih Zh. M. Sizova Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety Антибиотики и Химиотерапия drug interactions pipofezin metabolism substrates inducers and inhibitors of cytochrome isoenzymes p4503a4 p4501a2 electrochemical method |
| title | Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety |
| title_full | Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety |
| title_fullStr | Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety |
| title_full_unstemmed | Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety |
| title_short | Preclinical Investigation of Pharmaceuticals Impact Against Cytochrome P450 Activity and Prognosis of Substrate Affinity as Means for Providing Substrate Therapy Safety |
| title_sort | preclinical investigation of pharmaceuticals impact against cytochrome p450 activity and prognosis of substrate affinity as means for providing substrate therapy safety |
| topic | drug interactions pipofezin metabolism substrates inducers and inhibitors of cytochrome isoenzymes p4503a4 p4501a2 electrochemical method |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/499 |
| work_keys_str_mv | AT evfomin preclinicalinvestigationofpharmaceuticalsimpactagainstcytochromep450activityandprognosisofsubstrateaffinityasmeansforprovidingsubstratetherapysafety AT ihbaychorov preclinicalinvestigationofpharmaceuticalsimpactagainstcytochromep450activityandprognosisofsubstrateaffinityasmeansforprovidingsubstratetherapysafety AT evshih preclinicalinvestigationofpharmaceuticalsimpactagainstcytochromep450activityandprognosisofsubstrateaffinityasmeansforprovidingsubstratetherapysafety AT zhmsizova preclinicalinvestigationofpharmaceuticalsimpactagainstcytochromep450activityandprognosisofsubstrateaffinityasmeansforprovidingsubstratetherapysafety |