Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup?
The production 18F-FDG for positron emission tomography (PET) has consistently increased over the past two decades. The risk of internal contamination at 18F-FDG production facilities exists. A setup for evaluation of the 18F-FDG activity incorporated into the OEW brain, called Head Counting System...
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2019-07-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/880 |
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| author | Bruno Melo Mendes Bruno Machado Trindade Telma Cristina Ferreira Fonseca Tarcisio Passos Ribeiro de Campos |
| author_facet | Bruno Melo Mendes Bruno Machado Trindade Telma Cristina Ferreira Fonseca Tarcisio Passos Ribeiro de Campos |
| author_sort | Bruno Melo Mendes |
| collection | DOAJ |
| description | The production 18F-FDG for positron emission tomography (PET) has consistently increased over the past two decades. The risk of internal contamination at 18F-FDG production facilities exists. A setup for evaluation of the 18F-FDG activity incorporated into the OEW brain, called Head Counting System (HCS), was presented in previous works. In this study, the whole body counter setup (WBC) was evaluated for monitoring 18F incorporations. The Monte Carlo Virtual Software (VMC in-vivo) and the MCNPx code were used to assess the system calibration coefficient (CC). Three 18F distributions were simulated: i) uniformly distributed in soft tissue (UDST); ii) Na18F biodistribution (NAFB); and iii) 18F-FDG biodistribution (FDGB). The calibration coefficient of WBC was compared to the current head counting system CC under the same biodistribution conditions. The ICRP male reference voxelized phantoms (RCP_AM) was used in the simulations. The results showed that the WBC setup was more efficient than the head counter for all the studied 18F distributions: UDST = 1060 %, FDGB = 488 % and NAFB = 340 %. Despite this, especially for 18F-FDG, the possibility of bladder voiding before measurement can lead to considerable uncertainties when the WBC setup is used. On the other hand, bladder activity does not show great influence the calibration coefficient of the head counting system. Future work will evaluate the WBC sources of uncertainties in the measurement of 18F incorporated activity. |
| format | Article |
| id | doaj-art-66c3bb86f8cb4149b5db549b97d8318d |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-66c3bb86f8cb4149b5db549b97d8318d2025-08-20T03:27:36ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122019-07-0173A (Suppl.)10.15392/bjrs.v7i3A.880689Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup?Bruno Melo Mendes0Bruno Machado Trindade1Telma Cristina Ferreira Fonseca2Tarcisio Passos Ribeiro de Campos3Centro de Desenvolvimento da Tecnologia Nuclear - CDTN/CNENUniversity of Ottawa. Ottawa, Ontario, CanadaUniversidade Federal de Minas Gerais – UFMGUniversidade Federal de Minas Gerais – UFMGThe production 18F-FDG for positron emission tomography (PET) has consistently increased over the past two decades. The risk of internal contamination at 18F-FDG production facilities exists. A setup for evaluation of the 18F-FDG activity incorporated into the OEW brain, called Head Counting System (HCS), was presented in previous works. In this study, the whole body counter setup (WBC) was evaluated for monitoring 18F incorporations. The Monte Carlo Virtual Software (VMC in-vivo) and the MCNPx code were used to assess the system calibration coefficient (CC). Three 18F distributions were simulated: i) uniformly distributed in soft tissue (UDST); ii) Na18F biodistribution (NAFB); and iii) 18F-FDG biodistribution (FDGB). The calibration coefficient of WBC was compared to the current head counting system CC under the same biodistribution conditions. The ICRP male reference voxelized phantoms (RCP_AM) was used in the simulations. The results showed that the WBC setup was more efficient than the head counter for all the studied 18F distributions: UDST = 1060 %, FDGB = 488 % and NAFB = 340 %. Despite this, especially for 18F-FDG, the possibility of bladder voiding before measurement can lead to considerable uncertainties when the WBC setup is used. On the other hand, bladder activity does not show great influence the calibration coefficient of the head counting system. Future work will evaluate the WBC sources of uncertainties in the measurement of 18F incorporated activity.https://bjrs.org.br/revista/index.php/REVISTA/article/view/880internal dosimetrymcnpxvmc in-vivo18f-fdg incorporation |
| spellingShingle | Bruno Melo Mendes Bruno Machado Trindade Telma Cristina Ferreira Fonseca Tarcisio Passos Ribeiro de Campos Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup? Brazilian Journal of Radiation Sciences internal dosimetry mcnpx vmc in-vivo 18f-fdg incorporation |
| title | Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup? |
| title_full | Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup? |
| title_fullStr | Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup? |
| title_full_unstemmed | Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup? |
| title_short | Monitoring internal contamination from OEW of an 18F-FDG production plant: WBC or head counting setup? |
| title_sort | monitoring internal contamination from oew of an 18f fdg production plant wbc or head counting setup |
| topic | internal dosimetry mcnpx vmc in-vivo 18f-fdg incorporation |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/880 |
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