Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector

Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrP<sup>C</sup>) into the pathogenic PrP<sup>Sc</sup> isoform. Previous studies have identified nanobodies that speci...

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Bibliographic Details
Main Authors: Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pathogens
Subjects:
prion
transmissible spongiform encephalopathy
nanobody
therapy
adeno-associated virus
Online Access:https://www.mdpi.com/2076-0817/14/2/131
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