Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo

Genetically encoded affinity reagents are a toolkit for visualizing and manipulating endogenous protein function in vivo

Abstract Probing endogenous protein localization and function in vivo remains challenging due to laborious gene targeting and monofunctional alleles. Here, we develop a multifunctional and adaptable toolkit based on genetically encoded affinity reagents (GEARs). GEARs use small epitopes recognized b...

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Bibliographic Details
Main Authors: Curtis W. Boswell, Caroline Hoppe, Alice Sherrard, Liyun Miao, Mina L. Kojima, Pieter Martino, Ning Zhao, Timothy J. Stasevich, Stefania Nicoli, Antonio J. Giraldez
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61003-w
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