From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review
Neurovascular coupling (NVC) refers to the process of local changes in cerebral blood flow (CBF) after neuronal activity, which ensures the timely and adequate supply of oxygen, glucose, and substrates to the active regions of the brain. Recent clinical imaging and experimental technology advancemen...
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2024-12-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/1/16 |
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| author | Lu Yang Wenbo Zhao Yuan Kan Changhong Ren Xunming Ji |
| author_facet | Lu Yang Wenbo Zhao Yuan Kan Changhong Ren Xunming Ji |
| author_sort | Lu Yang |
| collection | DOAJ |
| description | Neurovascular coupling (NVC) refers to the process of local changes in cerebral blood flow (CBF) after neuronal activity, which ensures the timely and adequate supply of oxygen, glucose, and substrates to the active regions of the brain. Recent clinical imaging and experimental technology advancements have deepened our understanding of the cellular mechanisms underlying NVC. Pathological conditions such as stroke, subarachnoid hemorrhage, cerebral small vascular disease, and vascular cognitive impairment can disrupt NVC even before clinical symptoms appear. However, the complexity of the underlying mechanism remains unclear. This review discusses basic and clinical experimental evidence on how neural activity sensitively communicates with the vasculature to cause spatial changes in blood flow in cerebrovascular diseases. A deeper understanding of how neurovascular unit-related cells participate in NVC regulation is necessary to better understand blood flow and nerve activity recovery in cerebrovascular diseases. |
| format | Article |
| id | doaj-art-66bbd415d45b4c17ae4d0c6d4bce1cbc |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-66bbd415d45b4c17ae4d0c6d4bce1cbc2025-01-10T13:16:15ZengMDPI AGCells2073-44092024-12-011411610.3390/cells14010016From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative ReviewLu Yang0Wenbo Zhao1Yuan Kan2Changhong Ren3Xunming Ji4Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaBeijing Institute of Brain Disorders, Capital Medical University, Beijing 100054, ChinaBeijing Institute of Brain Disorders, Capital Medical University, Beijing 100054, ChinaNeurovascular coupling (NVC) refers to the process of local changes in cerebral blood flow (CBF) after neuronal activity, which ensures the timely and adequate supply of oxygen, glucose, and substrates to the active regions of the brain. Recent clinical imaging and experimental technology advancements have deepened our understanding of the cellular mechanisms underlying NVC. Pathological conditions such as stroke, subarachnoid hemorrhage, cerebral small vascular disease, and vascular cognitive impairment can disrupt NVC even before clinical symptoms appear. However, the complexity of the underlying mechanism remains unclear. This review discusses basic and clinical experimental evidence on how neural activity sensitively communicates with the vasculature to cause spatial changes in blood flow in cerebrovascular diseases. A deeper understanding of how neurovascular unit-related cells participate in NVC regulation is necessary to better understand blood flow and nerve activity recovery in cerebrovascular diseases.https://www.mdpi.com/2073-4409/14/1/16neurovascular couplingfunctional hyperemiacerebrovascular diseasesneurovascular unitcerebral blood flow |
| spellingShingle | Lu Yang Wenbo Zhao Yuan Kan Changhong Ren Xunming Ji From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review Cells neurovascular coupling functional hyperemia cerebrovascular diseases neurovascular unit cerebral blood flow |
| title | From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review |
| title_full | From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review |
| title_fullStr | From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review |
| title_full_unstemmed | From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review |
| title_short | From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review |
| title_sort | from mechanisms to medicine neurovascular coupling in the diagnosis and treatment of cerebrovascular disorders a narrative review |
| topic | neurovascular coupling functional hyperemia cerebrovascular diseases neurovascular unit cerebral blood flow |
| url | https://www.mdpi.com/2073-4409/14/1/16 |
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