Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases
The development of vascularized organoids as novel modelling tools of the human cardio-cerebrovascular system for preclinical research has become an essential platform for studying human vascularized tissues/organs for development of personalized therapeutics during recent decades. Organ-on-chip tec...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | American Heart Journal Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602225000230 |
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| author | Xi Chen Weiping Lin Micky Daniel Tortorella |
| author_facet | Xi Chen Weiping Lin Micky Daniel Tortorella |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | The development of vascularized organoids as novel modelling tools of the human cardio-cerebrovascular system for preclinical research has become an essential platform for studying human vascularized tissues/organs for development of personalized therapeutics during recent decades. Organ-on-chip technology is promising for investigating physiological in vitro responses in drug screening development and advanced disease models. Vascularized tissue/organ-on-a-chip benefits every step of drug discovery pipeline as a screening tool with close human genome relevance to investigate human systems biology. Simultaneously, cardio-cerebrovascular-on-chip-integrated microfluidic system serves as an alternative to preclinical animal research for studying (patho-)physiological processes of human blood vessels during embryonic development and cardio-cerebrovascular disease. Integrated with next-generation techniques, such as three-dimensional bioprinting of both cells and matrix, may enable vascularized organoid-on-chip-based novel drug development as personalized therapeutics. |
| format | Article |
| id | doaj-art-66b1d45bae2042c0b03b9e0d435e9de1 |
| institution | OA Journals |
| issn | 2666-6022 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj-art-66b1d45bae2042c0b03b9e0d435e9de12025-08-20T02:12:14ZengElsevierAmerican Heart Journal Plus2666-60222025-05-015310052010.1016/j.ahjo.2025.100520Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseasesXi Chen0Weiping Lin1Micky Daniel Tortorella2Cardiovascular Research Institute & Department of Physiology, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USABarts and The London School of Medicine and Dentistry, Queen Mary University, London, UK; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, CAS, Hong Kong SAR China; Corresponding authors.Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, CAS, Hong Kong SAR China; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Corresponding authors.The development of vascularized organoids as novel modelling tools of the human cardio-cerebrovascular system for preclinical research has become an essential platform for studying human vascularized tissues/organs for development of personalized therapeutics during recent decades. Organ-on-chip technology is promising for investigating physiological in vitro responses in drug screening development and advanced disease models. Vascularized tissue/organ-on-a-chip benefits every step of drug discovery pipeline as a screening tool with close human genome relevance to investigate human systems biology. Simultaneously, cardio-cerebrovascular-on-chip-integrated microfluidic system serves as an alternative to preclinical animal research for studying (patho-)physiological processes of human blood vessels during embryonic development and cardio-cerebrovascular disease. Integrated with next-generation techniques, such as three-dimensional bioprinting of both cells and matrix, may enable vascularized organoid-on-chip-based novel drug development as personalized therapeutics.http://www.sciencedirect.com/science/article/pii/S2666602225000230Vasculature developmentDrug discoveryCardio-cerebrovascular diseaseSystems biology |
| spellingShingle | Xi Chen Weiping Lin Micky Daniel Tortorella Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases American Heart Journal Plus Vasculature development Drug discovery Cardio-cerebrovascular disease Systems biology |
| title | Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases |
| title_full | Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases |
| title_fullStr | Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases |
| title_full_unstemmed | Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases |
| title_short | Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases |
| title_sort | towards advanced regenerative therapeutics to tackle cardio cerebrovascular diseases |
| topic | Vasculature development Drug discovery Cardio-cerebrovascular disease Systems biology |
| url | http://www.sciencedirect.com/science/article/pii/S2666602225000230 |
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