Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children
Abstract Purpose The aim of this study was to analyze the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children to provide a basis for clinical recognition and diagnosis. Methods This was a retrospective analysis of 130 cases of severe Mycoplas...
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2025-05-01
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| Online Access: | https://doi.org/10.1186/s12887-025-05804-4 |
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| author | Jie Liu Beibei Bao Tipei Zhang Wanyu Jia Caili Guo Chunlan Song |
| author_facet | Jie Liu Beibei Bao Tipei Zhang Wanyu Jia Caili Guo Chunlan Song |
| author_sort | Jie Liu |
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| description | Abstract Purpose The aim of this study was to analyze the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children to provide a basis for clinical recognition and diagnosis. Methods This was a retrospective analysis of 130 cases of severe Mycoplasma pneumoniae pneumonia (SMPP), 81 cases of severe Streptococcus pneumoniae pneumonia (SPP) and 105 cases of severe Haemophilus influenzae pneumonia (SHIP) in children. Demographic, clinical, laboratory, and imaging data were compared between groups. One-way analysis of variance or Kruskal-Wallis test was used for continuous variables, chi-square test was used for categorical variables, and rank-sum test was used for ranked data. The level of statistical significance was set at P < 0.05. Results All groups showed male predominance (P < 0.05). The SMPP group had older patients, longer hospital stays, prolonged fever, and higher interleukin-6, lactate dehydrogenase, and D-dimer levels (P < 0.05). Imaging revealed a higher proportion of unilateral solid lung lesions in SMPP, with increased tracheal stenosis, emphysema, pleural effusion, and pulmonary embolism (P < 0.05). Fiberoptic bronchoscopy detected more sputum plugs in SMPP (P < 0.05). Conversely, SPP and SHIP groups had younger patients, more wet rales/wheezing, higher white blood cell counts and neutrophil ratios, and bilateral patchy lung shadows (P < 0.05). Conclusion Differences in age of onset, laboratory tests, like IL-6, and imaging manifestations between SMPP and severe bacterial pneumonia can help us to recognize them early and thus target treatment more appropriately. |
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| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj-art-66b1243d49de4b85a9557ebc930bf2b12025-08-20T02:00:03ZengBMCBMC Pediatrics1471-24312025-05-012511910.1186/s12887-025-05804-4Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in childrenJie Liu0Beibei Bao1Tipei Zhang2Wanyu Jia3Caili Guo4Chunlan Song5Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s HospitalHenan University of Chinese Medicine, The First Affiliated Hospital of Henan University of Chinese MedicineHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s HospitalHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s HospitalHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s HospitalHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s HospitalAbstract Purpose The aim of this study was to analyze the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children to provide a basis for clinical recognition and diagnosis. Methods This was a retrospective analysis of 130 cases of severe Mycoplasma pneumoniae pneumonia (SMPP), 81 cases of severe Streptococcus pneumoniae pneumonia (SPP) and 105 cases of severe Haemophilus influenzae pneumonia (SHIP) in children. Demographic, clinical, laboratory, and imaging data were compared between groups. One-way analysis of variance or Kruskal-Wallis test was used for continuous variables, chi-square test was used for categorical variables, and rank-sum test was used for ranked data. The level of statistical significance was set at P < 0.05. Results All groups showed male predominance (P < 0.05). The SMPP group had older patients, longer hospital stays, prolonged fever, and higher interleukin-6, lactate dehydrogenase, and D-dimer levels (P < 0.05). Imaging revealed a higher proportion of unilateral solid lung lesions in SMPP, with increased tracheal stenosis, emphysema, pleural effusion, and pulmonary embolism (P < 0.05). Fiberoptic bronchoscopy detected more sputum plugs in SMPP (P < 0.05). Conversely, SPP and SHIP groups had younger patients, more wet rales/wheezing, higher white blood cell counts and neutrophil ratios, and bilateral patchy lung shadows (P < 0.05). Conclusion Differences in age of onset, laboratory tests, like IL-6, and imaging manifestations between SMPP and severe bacterial pneumonia can help us to recognize them early and thus target treatment more appropriately.https://doi.org/10.1186/s12887-025-05804-4Severe pneumoniaMycoplasma pneumoniaeStreptococcus pneumoniaeHaemophilus influenzaeClinical characteristics |
| spellingShingle | Jie Liu Beibei Bao Tipei Zhang Wanyu Jia Caili Guo Chunlan Song Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children BMC Pediatrics Severe pneumonia Mycoplasma pneumoniae Streptococcus pneumoniae Haemophilus influenzae Clinical characteristics |
| title | Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children |
| title_full | Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children |
| title_fullStr | Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children |
| title_full_unstemmed | Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children |
| title_short | Comparative analysis of the clinical characteristics of severe Mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children |
| title_sort | comparative analysis of the clinical characteristics of severe mycoplasma pneumoniae pneumonia and severe bacterial pneumonia in children |
| topic | Severe pneumonia Mycoplasma pneumoniae Streptococcus pneumoniae Haemophilus influenzae Clinical characteristics |
| url | https://doi.org/10.1186/s12887-025-05804-4 |
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