Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population
Endosulfan and hexachlorobenzene (HCB) were previously widely used organochlorine pesticides. Much attention has been paid to trends in human exposure to endosulfan and HCB and to the transport and distribution of endosulfan and HCB within the body. We determined endosulfan I, endosulfan II, and HCB...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Emerging Contaminants |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665024000933 |
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| author | Yuhao Fan Junsong Bao Ye Wu Xinyu Lou Dan Chen Junjie Jiang Jiali Han Yinuo Yang Yuxiang Qiao Lei Hou Jun Jin |
| author_facet | Yuhao Fan Junsong Bao Ye Wu Xinyu Lou Dan Chen Junjie Jiang Jiali Han Yinuo Yang Yuxiang Qiao Lei Hou Jun Jin |
| author_sort | Yuhao Fan |
| collection | DOAJ |
| description | Endosulfan and hexachlorobenzene (HCB) were previously widely used organochlorine pesticides. Much attention has been paid to trends in human exposure to endosulfan and HCB and to the transport and distribution of endosulfan and HCB within the body. We determined endosulfan I, endosulfan II, and HCB concentrations in serum samples collected from the general population of Wuxi in Jiangsu Province (China) between 2012 and 2016. The endosulfan concentrations varied little throughout the study period, but the HCB concentrations increased. The HCB concentrations were significantly higher in serum from overweight people and smokers than in serum from normal weight people (p = 0.028) and non-smokers (p = 0.011), respectively. HCB binds to human serum albumin (HSA) and can form halogen bonds to CYS-461 and ARG-484 at site II (subdomain IIIA). Fatty acids and nicotine increase the affinity between HCB and HSA, explaining the higher HCB concentrations in serum from overweight people and smokers than normal weight people and non-smokers, respectively. |
| format | Article |
| id | doaj-art-66a7936cff844bedad3de6a5a8c7dfe2 |
| institution | OA Journals |
| issn | 2405-6650 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Emerging Contaminants |
| spelling | doaj-art-66a7936cff844bedad3de6a5a8c7dfe22025-08-20T02:17:29ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502025-03-0111110039210.1016/j.emcon.2024.100392Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general populationYuhao Fan0Junsong Bao1Ye Wu2Xinyu Lou3Dan Chen4Junjie Jiang5Jiali Han6Yinuo Yang7Yuxiang Qiao8Lei Hou9Jun Jin10College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaState Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, ChinaCollege of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China; Engineering Research Center of Food Environment and Public Health, Beijing, 100081, China; Corresponding author. College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China.Endosulfan and hexachlorobenzene (HCB) were previously widely used organochlorine pesticides. Much attention has been paid to trends in human exposure to endosulfan and HCB and to the transport and distribution of endosulfan and HCB within the body. We determined endosulfan I, endosulfan II, and HCB concentrations in serum samples collected from the general population of Wuxi in Jiangsu Province (China) between 2012 and 2016. The endosulfan concentrations varied little throughout the study period, but the HCB concentrations increased. The HCB concentrations were significantly higher in serum from overweight people and smokers than in serum from normal weight people (p = 0.028) and non-smokers (p = 0.011), respectively. HCB binds to human serum albumin (HSA) and can form halogen bonds to CYS-461 and ARG-484 at site II (subdomain IIIA). Fatty acids and nicotine increase the affinity between HCB and HSA, explaining the higher HCB concentrations in serum from overweight people and smokers than normal weight people and non-smokers, respectively.http://www.sciencedirect.com/science/article/pii/S2405665024000933EndosulfanHCBTemporal trendHSASmokingObesity |
| spellingShingle | Yuhao Fan Junsong Bao Ye Wu Xinyu Lou Dan Chen Junjie Jiang Jiali Han Yinuo Yang Yuxiang Qiao Lei Hou Jun Jin Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population Emerging Contaminants Endosulfan HCB Temporal trend HSA Smoking Obesity |
| title | Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population |
| title_full | Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population |
| title_fullStr | Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population |
| title_full_unstemmed | Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population |
| title_short | Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population |
| title_sort | affinity of endosulfan and hcb with human serum albumin affects serum concentrations in a general population |
| topic | Endosulfan HCB Temporal trend HSA Smoking Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2405665024000933 |
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