Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg
Apolipoprotein A-I is a key structure protein of antiatherogenic high density lipoproteins (HDL). The aim of the study was to investigate the relationship between (-75)G/A and 83C/T polymorphic variants of apolipoprotein A-I gene (APOA1) and the plasma lipid profile in the population of Saint-Peters...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2014-03-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/20 |
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| author | V. V. Miroshnikova A. A. Panteleeva S. N. Pchelina A. L. Schwarzman |
| author_facet | V. V. Miroshnikova A. A. Panteleeva S. N. Pchelina A. L. Schwarzman |
| author_sort | V. V. Miroshnikova |
| collection | DOAJ |
| description | Apolipoprotein A-I is a key structure protein of antiatherogenic high density lipoproteins (HDL). The aim of the study was to investigate the relationship between (-75)G/A and 83C/T polymorphic variants of apolipoprotein A-I gene (APOA1) and the plasma lipid profile in the population of Saint-Petersburg. Allele T83 of APOA1 gene was found to be associated with the reduced risk of atherosclerosis development among Saint-Petersburg inhabitants. The study demonstrates that allele T83 of APOA1 gene is associated with higher plasma HDL cholesterol levels (p |
| format | Article |
| id | doaj-art-66a39dfd005d47df86e15bd6e1ba1326 |
| institution | DOAJ |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2014-03-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-66a39dfd005d47df86e15bd6e1ba13262025-08-20T03:21:34ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072014-03-01211575910.24884/1607-4181-2014-21-1-57-5916Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-PetersburgV. V. Miroshnikova0A. A. Panteleeva1S. N. Pchelina2A. L. Schwarzman3Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. КонстантиноваПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. КонстантиноваПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. КонстантиноваПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. КонстантиноваApolipoprotein A-I is a key structure protein of antiatherogenic high density lipoproteins (HDL). The aim of the study was to investigate the relationship between (-75)G/A and 83C/T polymorphic variants of apolipoprotein A-I gene (APOA1) and the plasma lipid profile in the population of Saint-Petersburg. Allele T83 of APOA1 gene was found to be associated with the reduced risk of atherosclerosis development among Saint-Petersburg inhabitants. The study demonstrates that allele T83 of APOA1 gene is associated with higher plasma HDL cholesterol levels (phttps://www.sci-notes.ru/jour/article/view/20аполипопротеин а-iген apoa1липопротеины высокой плотностиатеросклерозapolipoprotein a-iapoa1 genehigh density lipoproteinsatherosclerosis |
| spellingShingle | V. V. Miroshnikova A. A. Panteleeva S. N. Pchelina A. L. Schwarzman Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова аполипопротеин а-i ген apoa1 липопротеины высокой плотности атеросклероз apolipoprotein a-i apoa1 gene high density lipoproteins atherosclerosis |
| title | Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg |
| title_full | Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg |
| title_fullStr | Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg |
| title_full_unstemmed | Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg |
| title_short | Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg |
| title_sort | association of polymorphisms in apolipoprotein a i gene with plasma lipid profile in population of saint petersburg |
| topic | аполипопротеин а-i ген apoa1 липопротеины высокой плотности атеросклероз apolipoprotein a-i apoa1 gene high density lipoproteins atherosclerosis |
| url | https://www.sci-notes.ru/jour/article/view/20 |
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