Spatial structure facilitates evolutionary rescue by drug resistance.
Bacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how spatial structure affects the evolution of antibiotic resistance in a bacterial population. We consider a minimal model of spatially structured populations where all demes (i.e., subpopu...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-04-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1012861 |
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| author | Cecilia Fruet Ella Linxia Müller Claude Loverdo Anne-Florence Bitbol |
| author_facet | Cecilia Fruet Ella Linxia Müller Claude Loverdo Anne-Florence Bitbol |
| author_sort | Cecilia Fruet |
| collection | DOAJ |
| description | Bacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how spatial structure affects the evolution of antibiotic resistance in a bacterial population. We consider a minimal model of spatially structured populations where all demes (i.e., subpopulations) are identical and connected to each other by identical migration rates. We show that spatial structure can facilitate the survival of a bacterial population to antibiotic treatment, starting from a sensitive inoculum. Specifically, the bacterial population can be rescued if antibiotic resistant mutants appear and are present when drug is added, and spatial structure can impact the fate of these mutants and the probability that they are present. Indeed, the probability of fixation of neutral or deleterious mutations providing drug resistance is increased in smaller populations. This promotes local fixation of resistant mutants in the structured population, which facilitates evolutionary rescue by drug resistance in the rare mutation regime. Once the population is rescued by resistance, migrations allow resistant mutants to spread in all demes. Our main result that spatial structure facilitates evolutionary rescue by antibiotic resistance extends to more complex spatial structures, and to the case where there are resistant mutants in the inoculum. |
| format | Article |
| id | doaj-art-66a39b147f284640862dd2edf525f62f |
| institution | DOAJ |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-66a39b147f284640862dd2edf525f62f2025-08-20T03:05:18ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582025-04-01214e101286110.1371/journal.pcbi.1012861Spatial structure facilitates evolutionary rescue by drug resistance.Cecilia FruetElla Linxia MüllerClaude LoverdoAnne-Florence BitbolBacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how spatial structure affects the evolution of antibiotic resistance in a bacterial population. We consider a minimal model of spatially structured populations where all demes (i.e., subpopulations) are identical and connected to each other by identical migration rates. We show that spatial structure can facilitate the survival of a bacterial population to antibiotic treatment, starting from a sensitive inoculum. Specifically, the bacterial population can be rescued if antibiotic resistant mutants appear and are present when drug is added, and spatial structure can impact the fate of these mutants and the probability that they are present. Indeed, the probability of fixation of neutral or deleterious mutations providing drug resistance is increased in smaller populations. This promotes local fixation of resistant mutants in the structured population, which facilitates evolutionary rescue by drug resistance in the rare mutation regime. Once the population is rescued by resistance, migrations allow resistant mutants to spread in all demes. Our main result that spatial structure facilitates evolutionary rescue by antibiotic resistance extends to more complex spatial structures, and to the case where there are resistant mutants in the inoculum.https://doi.org/10.1371/journal.pcbi.1012861 |
| spellingShingle | Cecilia Fruet Ella Linxia Müller Claude Loverdo Anne-Florence Bitbol Spatial structure facilitates evolutionary rescue by drug resistance. PLoS Computational Biology |
| title | Spatial structure facilitates evolutionary rescue by drug resistance. |
| title_full | Spatial structure facilitates evolutionary rescue by drug resistance. |
| title_fullStr | Spatial structure facilitates evolutionary rescue by drug resistance. |
| title_full_unstemmed | Spatial structure facilitates evolutionary rescue by drug resistance. |
| title_short | Spatial structure facilitates evolutionary rescue by drug resistance. |
| title_sort | spatial structure facilitates evolutionary rescue by drug resistance |
| url | https://doi.org/10.1371/journal.pcbi.1012861 |
| work_keys_str_mv | AT ceciliafruet spatialstructurefacilitatesevolutionaryrescuebydrugresistance AT ellalinxiamuller spatialstructurefacilitatesevolutionaryrescuebydrugresistance AT claudeloverdo spatialstructurefacilitatesevolutionaryrescuebydrugresistance AT anneflorencebitbol spatialstructurefacilitatesevolutionaryrescuebydrugresistance |