JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient.
JC virus disease is a rare infectious complication after allogeneic hematopoietic stem cell transplantation. There is a few data in the literature on the frequency of JCV after allogeneic umbilical cord blood transplantation (UCBT). We describe a rare occurrence of Progressive multifocal leuko-encep...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2012-06-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/397 |
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| author | jean elcheikh |
| author_facet | jean elcheikh |
| author_sort | jean elcheikh |
| collection | DOAJ |
| description | JC virus disease is a rare infectious complication after allogeneic hematopoietic stem cell transplantation. There is a few data in the literature on the frequency of JCV after allogeneic umbilical cord blood transplantation (UCBT). We describe a rare occurrence of Progressive multifocal leuko-encephalopathy (PML), with a rapidly fatal outcome, in one patient after UCBT.
This case report demonstrates that patients presenting neurological symptoms after UCBT, the JCV encephalitis must be early suspected. These findings could have practical implications in patients presenting neurological symptoms and radiological signs after UCBT. Unfortunately inadequate drug penetration and the multi antiviral resistance as well as the severely immuno-suppressed state of this patient may have contributed to treatment failure. |
| format | Article |
| id | doaj-art-66979cacad3f41adb2202bf9d78a888c |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-66979cacad3f41adb2202bf9d78a888c2025-01-02T06:45:25ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062012-06-0141e2012043e201204310.4084/mjhid.2012.043289JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient.jean elcheikh0institut paoli calmettes marseille franceJC virus disease is a rare infectious complication after allogeneic hematopoietic stem cell transplantation. There is a few data in the literature on the frequency of JCV after allogeneic umbilical cord blood transplantation (UCBT). We describe a rare occurrence of Progressive multifocal leuko-encephalopathy (PML), with a rapidly fatal outcome, in one patient after UCBT. This case report demonstrates that patients presenting neurological symptoms after UCBT, the JCV encephalitis must be early suspected. These findings could have practical implications in patients presenting neurological symptoms and radiological signs after UCBT. Unfortunately inadequate drug penetration and the multi antiviral resistance as well as the severely immuno-suppressed state of this patient may have contributed to treatment failure.http://www.mjhid.org/index.php/mjhid/article/view/397JCV after allogeneic umbilical cord blood transplantation |
| spellingShingle | jean elcheikh JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient. Mediterranean Journal of Hematology and Infectious Diseases JCV after allogeneic umbilical cord blood transplantation |
| title | JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient. |
| title_full | JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient. |
| title_fullStr | JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient. |
| title_full_unstemmed | JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient. |
| title_short | JC Virus leuko-encephalopathy in reduced intensity conditioning cord blood transplant recipient. |
| title_sort | jc virus leuko encephalopathy in reduced intensity conditioning cord blood transplant recipient |
| topic | JCV after allogeneic umbilical cord blood transplantation |
| url | http://www.mjhid.org/index.php/mjhid/article/view/397 |
| work_keys_str_mv | AT jeanelcheikh jcvirusleukoencephalopathyinreducedintensityconditioningcordbloodtransplantrecipient |