Therapeutic Potential of Stem Cells in Follicle Regeneration
Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with a...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/1049641 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562948526047232 |
|---|---|
| author | Agnieszka Owczarczyk-Saczonek Magdalena Krajewska-Włodarczyk Anna Kruszewska Łukasz Banasiak Waldemar Placek Wojciech Maksymowicz Joanna Wojtkiewicz |
| author_facet | Agnieszka Owczarczyk-Saczonek Magdalena Krajewska-Włodarczyk Anna Kruszewska Łukasz Banasiak Waldemar Placek Wojciech Maksymowicz Joanna Wojtkiewicz |
| author_sort | Agnieszka Owczarczyk-Saczonek |
| collection | DOAJ |
| description | Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton’s jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment. |
| format | Article |
| id | doaj-art-66947d210fd24eaab0b3d874753babdd |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-66947d210fd24eaab0b3d874753babdd2025-02-03T01:21:25ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/10496411049641Therapeutic Potential of Stem Cells in Follicle RegenerationAgnieszka Owczarczyk-Saczonek0Magdalena Krajewska-Włodarczyk1Anna Kruszewska2Łukasz Banasiak3Waldemar Placek4Wojciech Maksymowicz5Joanna Wojtkiewicz6Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandDepartment of Rheumatology, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandDepartment of Plastic, Reconstructive and Aesthetic Surgery, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Toruń, PolandDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandDepartment of Neurology and Neurosurgery, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandFoundation for Nerve Cell Regeneration, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandAlopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton’s jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment.http://dx.doi.org/10.1155/2018/1049641 |
| spellingShingle | Agnieszka Owczarczyk-Saczonek Magdalena Krajewska-Włodarczyk Anna Kruszewska Łukasz Banasiak Waldemar Placek Wojciech Maksymowicz Joanna Wojtkiewicz Therapeutic Potential of Stem Cells in Follicle Regeneration Stem Cells International |
| title | Therapeutic Potential of Stem Cells in Follicle Regeneration |
| title_full | Therapeutic Potential of Stem Cells in Follicle Regeneration |
| title_fullStr | Therapeutic Potential of Stem Cells in Follicle Regeneration |
| title_full_unstemmed | Therapeutic Potential of Stem Cells in Follicle Regeneration |
| title_short | Therapeutic Potential of Stem Cells in Follicle Regeneration |
| title_sort | therapeutic potential of stem cells in follicle regeneration |
| url | http://dx.doi.org/10.1155/2018/1049641 |
| work_keys_str_mv | AT agnieszkaowczarczyksaczonek therapeuticpotentialofstemcellsinfollicleregeneration AT magdalenakrajewskawłodarczyk therapeuticpotentialofstemcellsinfollicleregeneration AT annakruszewska therapeuticpotentialofstemcellsinfollicleregeneration AT łukaszbanasiak therapeuticpotentialofstemcellsinfollicleregeneration AT waldemarplacek therapeuticpotentialofstemcellsinfollicleregeneration AT wojciechmaksymowicz therapeuticpotentialofstemcellsinfollicleregeneration AT joannawojtkiewicz therapeuticpotentialofstemcellsinfollicleregeneration |