Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models

Inhibition of the chemokine receptors CXCR1 and CXCR2 synergizes with docetaxel for effective tumor control and remodeling of the immune microenvironment of HPV-negative head and neck cancer models

Abstract Background Relapsed head and neck squamous cell carcinoma (HNSCC) unrelated to HPV infection carries a poor prognosis. Novel approaches are needed to improve the clinical outcome and prolong survival in this patient population which has poor long-term responses to immune checkpoint blockade...

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Bibliographic Details
Main Authors: Lucas A. Horn, Hanne Lind, Kristen Fousek, Haiyan Qin, Nika Rajabian, Shantel Angstadt, Nicole Hsiao-Sanchez, Miriam M. Medina-Enriquez, Marcus D. Kelly, Clint T. Allen, Sarah M. Hammoudeh, Roberto Weigert, Dean Y. Maeda, John A. Zebala, Claudia Palena
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HNSCC
CXCR1
CXCR2
IL-8
Docetaxel
Immunotherapy
Online Access:https://doi.org/10.1186/s13046-024-03240-3
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