Emerging roles of checkpoint molecules on B cells
Immune checkpoint molecules, including both co-inhibitory molecules and co-stimulatory molecules, are known to play critical roles in regulating T-cell responses. During the last decades, immunotherapies targeting these molecules (such as programmed cell death 1 (PD-1), and lymphocyte activation gen...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-01-01
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| Series: | Immunological Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2025.2454045 |
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| author | Hiromitsu Asashima Satoshi Akao Isao Matsumoto |
| author_facet | Hiromitsu Asashima Satoshi Akao Isao Matsumoto |
| author_sort | Hiromitsu Asashima |
| collection | DOAJ |
| description | Immune checkpoint molecules, including both co-inhibitory molecules and co-stimulatory molecules, are known to play critical roles in regulating T-cell responses. During the last decades, immunotherapies targeting these molecules (such as programmed cell death 1 (PD-1), and lymphocyte activation gene 3 (LAG-3)) have provided clinical benefits in many cancers. It is becoming apparent that not only T cells, but also B cells have a capacity to express some checkpoint molecules. These were originally thought to be only the markers for regulatory B cells which produce IL-10, but recent studies suggest that these molecules (especially T-cell immunoglobulin and mucin domain 1 (TIM-1), T cell immunoreceptor with Ig and ITIM domains (TIGIT), and PD-1) can regulate intrinsic B-cell activation and functions. Here, we focus on these molecules and summarize their characteristics, ligands, and functions on B cells. |
| format | Article |
| id | doaj-art-668f49fc98114cc793c56f353ca9abd8 |
| institution | Kabale University |
| issn | 2578-5826 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj-art-668f49fc98114cc793c56f353ca9abd82025-01-17T13:26:24ZengTaylor & Francis GroupImmunological Medicine2578-58262025-01-0111210.1080/25785826.2025.2454045Emerging roles of checkpoint molecules on B cellsHiromitsu Asashima0Satoshi Akao1Isao Matsumoto2Department of Rheumatology, Institute of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Rheumatology, Institute of Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Rheumatology, Institute of Medicine, University of Tsukuba, Ibaraki, JapanImmune checkpoint molecules, including both co-inhibitory molecules and co-stimulatory molecules, are known to play critical roles in regulating T-cell responses. During the last decades, immunotherapies targeting these molecules (such as programmed cell death 1 (PD-1), and lymphocyte activation gene 3 (LAG-3)) have provided clinical benefits in many cancers. It is becoming apparent that not only T cells, but also B cells have a capacity to express some checkpoint molecules. These were originally thought to be only the markers for regulatory B cells which produce IL-10, but recent studies suggest that these molecules (especially T-cell immunoglobulin and mucin domain 1 (TIM-1), T cell immunoreceptor with Ig and ITIM domains (TIGIT), and PD-1) can regulate intrinsic B-cell activation and functions. Here, we focus on these molecules and summarize their characteristics, ligands, and functions on B cells.https://www.tandfonline.com/doi/10.1080/25785826.2025.2454045Regulatory B cellscheckpoint moleculesTIM-1TIGITPD-1 |
| spellingShingle | Hiromitsu Asashima Satoshi Akao Isao Matsumoto Emerging roles of checkpoint molecules on B cells Immunological Medicine Regulatory B cells checkpoint molecules TIM-1 TIGIT PD-1 |
| title | Emerging roles of checkpoint molecules on B cells |
| title_full | Emerging roles of checkpoint molecules on B cells |
| title_fullStr | Emerging roles of checkpoint molecules on B cells |
| title_full_unstemmed | Emerging roles of checkpoint molecules on B cells |
| title_short | Emerging roles of checkpoint molecules on B cells |
| title_sort | emerging roles of checkpoint molecules on b cells |
| topic | Regulatory B cells checkpoint molecules TIM-1 TIGIT PD-1 |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2025.2454045 |
| work_keys_str_mv | AT hiromitsuasashima emergingrolesofcheckpointmoleculesonbcells AT satoshiakao emergingrolesofcheckpointmoleculesonbcells AT isaomatsumoto emergingrolesofcheckpointmoleculesonbcells |