EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA
Purpose: to study the clinical and laboratory efficacy of the platelet autoplasma use in the complex treatment of endogenous uveitis associated with systemic diseases accompanied by macular edema. Material and methods. The study included 46 people (72 eyes) with endogenous uveitis and macular edema....
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-11-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/282 |
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| author | N. S. Arbeneva T. A. Chekhova V. I. Bratko O. O. Obukhovа O. M. Gorbenko A. P. Shvayuk O. V. Poveshchenko A. N. Trunov V. V. Chernykh |
| author_facet | N. S. Arbeneva T. A. Chekhova V. I. Bratko O. O. Obukhovа O. M. Gorbenko A. P. Shvayuk O. V. Poveshchenko A. N. Trunov V. V. Chernykh |
| author_sort | N. S. Arbeneva |
| collection | DOAJ |
| description | Purpose: to study the clinical and laboratory efficacy of the platelet autoplasma use in the complex treatment of endogenous uveitis associated with systemic diseases accompanied by macular edema. Material and methods. The study included 46 people (72 eyes) with endogenous uveitis and macular edema. The diagnosis was made on the basis of the ophthalmological examination, including visometry, tonometry, biomicroscopy, ophthalmoscopy, perimetry, B-scan, optical coherence tomography of the macular zone, photoregistration of the anterior, posterior segment of the eye. The examination was carried out on the 1st and 10th day of treatment. The main group consisted of 22 people (36 eyes) who underwent anti-inflammatory therapy and the introduction of platelet plasma in the region of the pterygopalatine fossa. The control group consisted of 24 people (36 eyes) receiving only anti-inflammatory therapy (diprospan 0.5 paraequatorially №1, dexazone 4 mg intravenously №5, intravenous lasix 2.0 ml №5, electrophoresis with prednisolone № 7). All patients underwent the definition of IL-4, IL-6, IL-8, IL-17 in tear fluid before the study and on the 10th day. Results. The significant increase in the concentrations of pro-inflammatory cytokines (IL-17A and IL-8) and IL-4 and IL-6 involved in the development of autoimmune response and chronic inflammation was found in the patients with endogenous uveitis and macular edema. The use in the treatment of endogenous uveitis with macular edema of platelet autoplasma leads to more pronounced improvement of clinico-ophthalmological parameters (improvement in visual acuity, retinal photosensitivity, and retinal thickness reduction) relating to the comparison group. A decrease in the activity of the inflammatory process was noted in the main group after treatment, which is manifested by a significant decrease in the concentrations of IL-17A, IL-8, IL-4, IL-6, relating to the data obtained in the comparison group. The proposed scheme of complex treatment allows reducing the frequency of relapses of the pathological process. |
| format | Article |
| id | doaj-art-668d7716143944d991f0abdcd3549ac7 |
| institution | Kabale University |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| publishDate | 2019-11-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj-art-668d7716143944d991f0abdcd3549ac72025-08-20T03:50:44ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-11-0139511011810.15372/SSMJ20190513194EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMAN. S. Arbeneva0T. A. Chekhova1V. I. Bratko2O. O. Obukhovа3O. M. Gorbenko4A. P. Shvayuk5O. V. Poveshchenko6A. N. Trunov7V. V. Chernykh8S. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk BranchS. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk BranchS. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk BranchResearch Institute for Experimental and Clinical Medicine of Federal Research Center or Fundamental and Translational MedicineResearch Institute for Experimental and Clinical Medicine of Federal Research Center or Fundamental and Translational MedicineResearch Institute for Experimental and Clinical Medicine of Federal Research Center or Fundamental and Translational MedicineResearch Institute for Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASS. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk Branch, Research Institute for Experimental and Clinical Medicine of Federal Research Center or Fundamental and Translational MedicineS. Fyodorov Eye Microsurgery Federal State Institution of Minzdrav of Russia, Novosibirsk BranchPurpose: to study the clinical and laboratory efficacy of the platelet autoplasma use in the complex treatment of endogenous uveitis associated with systemic diseases accompanied by macular edema. Material and methods. The study included 46 people (72 eyes) with endogenous uveitis and macular edema. The diagnosis was made on the basis of the ophthalmological examination, including visometry, tonometry, biomicroscopy, ophthalmoscopy, perimetry, B-scan, optical coherence tomography of the macular zone, photoregistration of the anterior, posterior segment of the eye. The examination was carried out on the 1st and 10th day of treatment. The main group consisted of 22 people (36 eyes) who underwent anti-inflammatory therapy and the introduction of platelet plasma in the region of the pterygopalatine fossa. The control group consisted of 24 people (36 eyes) receiving only anti-inflammatory therapy (diprospan 0.5 paraequatorially №1, dexazone 4 mg intravenously №5, intravenous lasix 2.0 ml №5, electrophoresis with prednisolone № 7). All patients underwent the definition of IL-4, IL-6, IL-8, IL-17 in tear fluid before the study and on the 10th day. Results. The significant increase in the concentrations of pro-inflammatory cytokines (IL-17A and IL-8) and IL-4 and IL-6 involved in the development of autoimmune response and chronic inflammation was found in the patients with endogenous uveitis and macular edema. The use in the treatment of endogenous uveitis with macular edema of platelet autoplasma leads to more pronounced improvement of clinico-ophthalmological parameters (improvement in visual acuity, retinal photosensitivity, and retinal thickness reduction) relating to the comparison group. A decrease in the activity of the inflammatory process was noted in the main group after treatment, which is manifested by a significant decrease in the concentrations of IL-17A, IL-8, IL-4, IL-6, relating to the data obtained in the comparison group. The proposed scheme of complex treatment allows reducing the frequency of relapses of the pathological process.https://sibmed.elpub.ru/jour/article/view/282endogenous uveitismacular edemacytokinesplatelet autoplasma |
| spellingShingle | N. S. Arbeneva T. A. Chekhova V. I. Bratko O. O. Obukhovа O. M. Gorbenko A. P. Shvayuk O. V. Poveshchenko A. N. Trunov V. V. Chernykh EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA Сибирский научный медицинский журнал endogenous uveitis macular edema cytokines platelet autoplasma |
| title | EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA |
| title_full | EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA |
| title_fullStr | EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA |
| title_full_unstemmed | EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA |
| title_short | EFFECT OF COMPLEX TREATMENT USING PLATELET AUTOPLASMA ON CLINICAL AND LABORATORY PARAMETERS OF PATIENTS WITH ENDOGENOUS UVEITIS AND MACULAR EDEMA |
| title_sort | effect of complex treatment using platelet autoplasma on clinical and laboratory parameters of patients with endogenous uveitis and macular edema |
| topic | endogenous uveitis macular edema cytokines platelet autoplasma |
| url | https://sibmed.elpub.ru/jour/article/view/282 |
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