The role of deubiquitinases in cardiac disease
Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399424000024/type/journal_article |
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| _version_ | 1849233044837236736 |
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| author | Xiaona Zhan Yi Yang Qing Li Fan He |
| author_facet | Xiaona Zhan Yi Yang Qing Li Fan He |
| author_sort | Xiaona Zhan |
| collection | DOAJ |
| description | Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future. |
| format | Article |
| id | doaj-art-668abcdc9e5a44e99faccb85abda24e5 |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-668abcdc9e5a44e99faccb85abda24e52025-08-20T12:57:31ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942024-01-012610.1017/erm.2024.2The role of deubiquitinases in cardiac diseaseXiaona Zhan0https://orcid.org/0000-0003-3076-1612Yi Yang1Qing Li2https://orcid.org/0000-0002-3171-4896Fan He3https://orcid.org/0000-0002-2487-5827Department of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of ChinaDeubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future.https://www.cambridge.org/core/product/identifier/S1462399424000024/type/journal_articlecardiac diseasecardiac fibrosiscardiac hypertrophydeubiquitinasesmyocardial ischaemia-reperfusion injurymyocarditis |
| spellingShingle | Xiaona Zhan Yi Yang Qing Li Fan He The role of deubiquitinases in cardiac disease Expert Reviews in Molecular Medicine cardiac disease cardiac fibrosis cardiac hypertrophy deubiquitinases myocardial ischaemia-reperfusion injury myocarditis |
| title | The role of deubiquitinases in cardiac disease |
| title_full | The role of deubiquitinases in cardiac disease |
| title_fullStr | The role of deubiquitinases in cardiac disease |
| title_full_unstemmed | The role of deubiquitinases in cardiac disease |
| title_short | The role of deubiquitinases in cardiac disease |
| title_sort | role of deubiquitinases in cardiac disease |
| topic | cardiac disease cardiac fibrosis cardiac hypertrophy deubiquitinases myocardial ischaemia-reperfusion injury myocarditis |
| url | https://www.cambridge.org/core/product/identifier/S1462399424000024/type/journal_article |
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