Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis
Introduction This study aims to evaluate the association between oral malignant and oral potentially malignant disorders with smoking and chewing forms of tobacco. Methods A search was conducted in Medline, Cochrane databases, Google Scholar, Scopus and Web of Science for studies up to December 202...
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| Format: | Article |
| Language: | English |
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European Publishing
2023-03-01
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| Series: | Population Medicine |
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| Online Access: | https://www.populationmedicine.eu/Oral-malignancy-oral-disorders-with-malignant-potential-and-their-association-with,160991,0,2.html |
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| _version_ | 1850203902535794688 |
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| author | Abhinav Singh Bharathi M. Purohit Abhishek Purohit |
| author_facet | Abhinav Singh Bharathi M. Purohit Abhishek Purohit |
| author_sort | Abhinav Singh |
| collection | DOAJ |
| description | Introduction
This study aims to evaluate the association
between oral malignant and oral potentially malignant
disorders with smoking and chewing forms of tobacco.
Methods
A search was conducted in Medline, Cochrane
databases, Google Scholar, Scopus and Web of Science for
studies up to December 2021. PRISMA guidelines were
followed for the meta-analysis. Participants were adolescent
children or adults with no age restrictions. Exposed to
the risk factors were participants with a habit of tobacco
chewing and/or smoking. Outcomes were oral malignancy
or other potentially malignant oral disorders. Quality
was evaluated using the Risk of Bias Assessment tool.
Random effects model was used to assess and compare the
association between smoking and chewing forms of tobacco
with the outcome measure. Assessment of certainty of
evidence was conducted using GRADE analysis.
Results
A total of 30764 tobacco smokers and 36134 tobacco chewers with oral cancer were available for analysis. Similarly, 4135 tobacco smokers and 4033 tobacco chewers were available for analysis for oral potentially malignant disorders. Tobacco chewers were significantly associated with higher presence of oral potentially malignant disorders among patients with both mixed (OR=2.20; 95% CI: 1.25–3.87, p=0.001; I 2 =93%) and no mixed usage (OR=2.63; 95% CI: 2.01–3.43, p=0.001; I 2 =44%) when compared with tobacco smokers with mixed and no mixed usage. Tobacco chewers were also significantly associated with higher presence of higher oral malignancy among patients with both mixed (OR=2.26; 95% CI: 1.19–4.28, p=0.01; I 2 =91%) and no mixed usage (OR=2.98; 95% CI: 1.62–5.46, p=0.001; I 2 =0%) when compared with tobacco smokers with mixed and no mixed usage.
Conclusions
This meta-analysis provides substantial
evidence that consumption of chewing tobacco is
significantly associated with higher oral malignancy and
oral potentially malignant disorders compared to smoking
tobacco. |
| format | Article |
| id | doaj-art-66863f9cbb714ab791e5a44ec3cb4891 |
| institution | OA Journals |
| issn | 2654-1459 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Population Medicine |
| spelling | doaj-art-66863f9cbb714ab791e5a44ec3cb48912025-08-20T02:11:24ZengEuropean PublishingPopulation Medicine2654-14592023-03-015March11110.18332/popmed/160991160991Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysisAbhinav Singh0https://orcid.org/0000-0002-8830-9955Bharathi M. Purohit1Abhishek Purohit2Department of Dentistry, Regional Training Centre for Oral Health Promotion and Dental Public Health in MP, All India Institute of Medical Sciences, Bhopal, IndiaDivision of Public Health Dentistry Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Dentistry, Regional Training Centre for Oral Health Promotion and Dental Public Health in MP, All India Institute of Medical Sciences, Bhopal, IndiaIntroduction This study aims to evaluate the association between oral malignant and oral potentially malignant disorders with smoking and chewing forms of tobacco. Methods A search was conducted in Medline, Cochrane databases, Google Scholar, Scopus and Web of Science for studies up to December 2021. PRISMA guidelines were followed for the meta-analysis. Participants were adolescent children or adults with no age restrictions. Exposed to the risk factors were participants with a habit of tobacco chewing and/or smoking. Outcomes were oral malignancy or other potentially malignant oral disorders. Quality was evaluated using the Risk of Bias Assessment tool. Random effects model was used to assess and compare the association between smoking and chewing forms of tobacco with the outcome measure. Assessment of certainty of evidence was conducted using GRADE analysis. Results A total of 30764 tobacco smokers and 36134 tobacco chewers with oral cancer were available for analysis. Similarly, 4135 tobacco smokers and 4033 tobacco chewers were available for analysis for oral potentially malignant disorders. Tobacco chewers were significantly associated with higher presence of oral potentially malignant disorders among patients with both mixed (OR=2.20; 95% CI: 1.25–3.87, p=0.001; I 2 =93%) and no mixed usage (OR=2.63; 95% CI: 2.01–3.43, p=0.001; I 2 =44%) when compared with tobacco smokers with mixed and no mixed usage. Tobacco chewers were also significantly associated with higher presence of higher oral malignancy among patients with both mixed (OR=2.26; 95% CI: 1.19–4.28, p=0.01; I 2 =91%) and no mixed usage (OR=2.98; 95% CI: 1.62–5.46, p=0.001; I 2 =0%) when compared with tobacco smokers with mixed and no mixed usage. Conclusions This meta-analysis provides substantial evidence that consumption of chewing tobacco is significantly associated with higher oral malignancy and oral potentially malignant disorders compared to smoking tobacco.https://www.populationmedicine.eu/Oral-malignancy-oral-disorders-with-malignant-potential-and-their-association-with,160991,0,2.htmlsmokingsmokeless tobaccooral cancerchewing tobaccoprecancerousconditions |
| spellingShingle | Abhinav Singh Bharathi M. Purohit Abhishek Purohit Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis Population Medicine smoking smokeless tobacco oral cancer chewing tobacco precancerous conditions |
| title | Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis |
| title_full | Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis |
| title_fullStr | Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis |
| title_full_unstemmed | Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis |
| title_short | Oral malignancy, oral disorders with malignant potential and their association with smoking and chewing forms of tobacco: A systematic review and meta-analysis |
| title_sort | oral malignancy oral disorders with malignant potential and their association with smoking and chewing forms of tobacco a systematic review and meta analysis |
| topic | smoking smokeless tobacco oral cancer chewing tobacco precancerous conditions |
| url | https://www.populationmedicine.eu/Oral-malignancy-oral-disorders-with-malignant-potential-and-their-association-with,160991,0,2.html |
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