Green-synthesized silver nanoparticles of Cinnamomum zeylanicum and their biological activities
Several drugs cure pathogenic microorganisms; however, they all have cost, toxicity, and pathogenic resistance. The present study was designed to evaluate the antibacterial, antifungal, and antileishmanial efficacy, as well as the toxicity profile, of nanoparticles (NPs). Synthesized silver nanopart...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2025-03-01
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| Series: | Open Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/chem-2024-0128 |
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| Summary: | Several drugs cure pathogenic microorganisms; however, they all have cost, toxicity, and pathogenic resistance. The present study was designed to evaluate the antibacterial, antifungal, and antileishmanial efficacy, as well as the toxicity profile, of nanoparticles (NPs). Synthesized silver nanoparticles (AgNPs) of Cinnamomum zeylanicum (C. zeylanicum) bark extract was characterized using several techniques were UV-visible spectroscopy verified NPs production. The absorption peak of C. zeylanicum bark extract was 418 nm. Fourier transform infrared spectroscopy used to identified the functional groups in plant extract responsible for reducing AgNO3 to AgNPs. Scanning electron microscopy showed AgNPs morphology. The synthesized NPs were spherical, rectangular, and oval. The synthesized NPs were analyzed for phase distribution, crystallinity, and purity using X-ray diffraction. C. zeylanicum bark extract AgNPs possess crystal cubic structure, and the Debye-Scherrer equation determined the average particle size of 10.508 nm from full width at half-maximum of the diffraction peaks. In this study, an environmentally friendly synthesis of AgNPs from C. zeylanicum bark extract was tested for antibacterial, antifungal, and antileishmanial efficacy against E. coli, S. aureus, Trichoderma harzianum, and Leishmania tropica (KWH23) strains. Fresh human blood cells were also tested. Green synthesized NPs were effective against pathogenic bacteria. Low dose of AgNPs can be used to reduce toxicity. |
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| ISSN: | 2391-5420 |