Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus
A 62-year-old man with type 2 diabetes mellitus, who had been on insulin therapy for the past 20 years, was found to have subcutaneous mass formation in the abdomen during a workup of worsened glycemic control. Because of suspected amyloid deposition, he was advised to avoid injections to the mass,...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/3985214 |
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| _version_ | 1850158857690546176 |
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| author | Seiya Hagiwara Shinji Taneda Takaya Fukumoto Kazuya Hagiwara Minoru Kikuchi Tetsunori Kimura Hidetaka Nakayama Naoki Manda |
| author_facet | Seiya Hagiwara Shinji Taneda Takaya Fukumoto Kazuya Hagiwara Minoru Kikuchi Tetsunori Kimura Hidetaka Nakayama Naoki Manda |
| author_sort | Seiya Hagiwara |
| collection | DOAJ |
| description | A 62-year-old man with type 2 diabetes mellitus, who had been on insulin therapy for the past 20 years, was found to have subcutaneous mass formation in the abdomen during a workup of worsened glycemic control. Because of suspected amyloid deposition, he was advised to avoid injections to the mass, which led to improvement of glycemic control. However, he strongly requested mass excision and was hospitalized. After evaluation using ultrasonography and computed tomography, a total mass excision was performed, and a diagnosis of insulin-derived amyloidosis was made. Comparison of the ultrasonographic and histopathological findings demonstrated that the location of the amyloid deposition nearly corresponded to the hypoechoic region. This case highlights that ultrasonography, which is a noninvasive imaging modality, can be useful for detection of insulin-derived amyloidosis. |
| format | Article |
| id | doaj-art-66856770d5a94b48b5f99eaae8b6aff1 |
| institution | OA Journals |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-66856770d5a94b48b5f99eaae8b6aff12025-08-20T02:23:45ZengWileyCase Reports in Endocrinology2090-65012090-651X2017-01-01201710.1155/2017/39852143985214Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes MellitusSeiya Hagiwara0Shinji Taneda1Takaya Fukumoto2Kazuya Hagiwara3Minoru Kikuchi4Tetsunori Kimura5Hidetaka Nakayama6Naoki Manda7Manda Memorial Hospital Diabetes Center, Sapporo, JapanManda Memorial Hospital Diabetes Center, Sapporo, JapanFukumoto Dermatopathology Clinic, Nara, JapanYamahana Dermatology Clinic, Sapporo, JapanManda Memorial Hospital Diabetes Center, Sapporo, JapanSapporo Dermatopathology Institute, Sapporo, JapanManda Memorial Hospital Diabetes Center, Sapporo, JapanManda Memorial Hospital Diabetes Center, Sapporo, JapanA 62-year-old man with type 2 diabetes mellitus, who had been on insulin therapy for the past 20 years, was found to have subcutaneous mass formation in the abdomen during a workup of worsened glycemic control. Because of suspected amyloid deposition, he was advised to avoid injections to the mass, which led to improvement of glycemic control. However, he strongly requested mass excision and was hospitalized. After evaluation using ultrasonography and computed tomography, a total mass excision was performed, and a diagnosis of insulin-derived amyloidosis was made. Comparison of the ultrasonographic and histopathological findings demonstrated that the location of the amyloid deposition nearly corresponded to the hypoechoic region. This case highlights that ultrasonography, which is a noninvasive imaging modality, can be useful for detection of insulin-derived amyloidosis.http://dx.doi.org/10.1155/2017/3985214 |
| spellingShingle | Seiya Hagiwara Shinji Taneda Takaya Fukumoto Kazuya Hagiwara Minoru Kikuchi Tetsunori Kimura Hidetaka Nakayama Naoki Manda Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus Case Reports in Endocrinology |
| title | Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus |
| title_full | Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus |
| title_fullStr | Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus |
| title_short | Localized Subcutaneous Insulin-Derived Amyloidosis Excised after Evaluation Using Ultrasonography in a Patient with Type 2 Diabetes Mellitus |
| title_sort | localized subcutaneous insulin derived amyloidosis excised after evaluation using ultrasonography in a patient with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2017/3985214 |
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