Baicalin Alleviates Piglet Immunosuppression Induced by <i>Glaesserella parasuis</i> via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy
<i>Glaesserella parasuis</i> (<i>G. parasuis</i>) causes vascular inflammation in piglets, resulting in vascular damage. However, the mechanism causing vascular inflammation remains unclear. Baicalin possesses an anti-inflammatory function. Tumor necrosis factor-like weak ind...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/5/722 |
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| Summary: | <i>Glaesserella parasuis</i> (<i>G. parasuis</i>) causes vascular inflammation in piglets, resulting in vascular damage. However, the mechanism causing vascular inflammation remains unclear. Baicalin possesses an anti-inflammatory function. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated in immunosuppression. CD163, a scavenger receptor expressed on macrophages that acts as a decoy receptor for TWEAK, plays a crucial role in the regulation of autophagy and inflammation. This research investigated the efficacy of baicalin in reducing immunosuppression elicited by <i>G. parasuis</i> through the regulation of CD163/TWEAK-mediated autophagy. The data demonstrated that <i>G. parasuis</i> altered routine blood indicators and biochemical parameters, increased cytokine production, and induced blood vessel tissue damage. <i>G. parasuis</i> reduced the CD3+ T cell proportion, CD3+CD4+ T cell proportion, and CD3+CD8+ T cell proportion in piglet blood. The proteomic analysis revealed that CD163 was differentially expressed in the blood vessels of challenged piglets. Baicalin was found to regulate CD163/TWEAK axis expression, inhibit Notch/Wnt signaling pathway activation, promote autophagy, and reduce NLRP3/Caspase 1 signaling pathway activation. Baicalin also decreased cytokine production and alleviated pathological tissue damage in the blood vessels of <i>G. parasuis</i>-challenged piglets. Taken together, this study indicates that baicalin alleviates <i>G. parasuis</i>-induced immunosuppression and might promote CD163/TWEAK-mediated autophagy. This finding suggests that baicalin could serve as a potential therapeutic agent to control <i>G. parasuis infection</i> and related vascular inflammation. |
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| ISSN: | 2218-273X |