Impact of cigarette smoking and gender on genetic architecture of body mass index
Obesity has been reported as an increasingly prevalent and highly heritable health problem, resulting in increased risk for several common diseases. Despite the consensus view, that epistasis and gene-environment interactions have a prominent role in its pathogenesis, they are largely ignored in the...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2014-07-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2014.05.021 |
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| Summary: | Obesity has been reported as an increasingly prevalent and highly heritable health problem, resulting in increased risk for several common diseases. Despite the consensus view, that epistasis and gene-environment interactions have a prominent role in its pathogenesis, they are largely ignored in the current genome-wide association study (GWAS). A new approach based on a linear mixed model was conducted for GWAS to detect plausible genes and potential interactions among genes, impacts of smoking and gender on body mass index (BMI). We conducted analysis based on database of genotype and phenotype (dbGaP) from chronic obstructive pulmonary disease (COPD) study, and identified 20 genes and two pairs of epistasis associated with BMI, some of which were smoking-influencing and gender-specific. Bioinformatics analysis revealed a complex gene network among the identified genes connected with BMI and other related diseases. These findings highlight that personalized measures including lifestyle modifications such as smoking is essential for prevention and treatment of obesity. |
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| ISSN: | 1008-9209 2097-5155 |