Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation
The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/6924601 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412972295749632 |
|---|---|
| author | Abdul Karim Muhammad Ashraf Shaheen Tahir Mehmood Abdul Rauf Raza Musadiq Aziz Badar Din |
| author_facet | Abdul Karim Muhammad Ashraf Shaheen Tahir Mehmood Abdul Rauf Raza Musadiq Aziz Badar Din |
| author_sort | Abdul Karim |
| collection | DOAJ |
| description | The float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32 factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT. |
| format | Article |
| id | doaj-art-666f55f9ce4b47fcb41235e274cb0e94 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-666f55f9ce4b47fcb41235e274cb0e942025-08-20T03:34:17ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/69246016924601Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and EvaluationAbdul Karim0Muhammad Ashraf Shaheen1Tahir Mehmood2Abdul Rauf Raza3Musadiq Aziz4Badar Din5Department of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, University of Sargodha, Sargodha 40100, PakistanDepartment of Chemistry, University of Sargodha, Sargodha 40100, PakistanThe float formulation is a strategy to improve the bioavailability of drugs by gastroretentive drug delivery system (GRDDS). A drug delivery model based on swellable and reswellable low density biopolymers has been designed to evaluate its drug release profile using ranitidine (RNT) as a model drug and formulations have been prepared utilizing 32 factorial designs. The drug release (DR) data has been subjected to various kinetic models to investigate the DR mechanism. A reduction in rate has been observed by expanding the amounts of PSG and LSG parts, while an expansion has been noted by increasing the concentration of tragacanth (TG) and citric acid (CA) with an increment in floating time. The stearic acid (SA) has been used to decrease the lag time because a decrease in density of system was observed. The kinetic analysis showed that the optimized formulation (S4F3) followed zero-order kinetics and power law was found to be best fitted due to its minimum lag time and maximum floating ability. The resemblance of observed and predicted values indicated the validity of derived equations for evaluating the effect of independent variables while kinetic study demonstrated that the applied models are feasible for evaluating and developing float for RNT.http://dx.doi.org/10.1155/2017/6924601 |
| spellingShingle | Abdul Karim Muhammad Ashraf Shaheen Tahir Mehmood Abdul Rauf Raza Musadiq Aziz Badar Din Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation Journal of Chemistry |
| title | Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation |
| title_full | Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation |
| title_fullStr | Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation |
| title_full_unstemmed | Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation |
| title_short | Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation |
| title_sort | ranitidine loaded biopolymer floats designing characterization and evaluation |
| url | http://dx.doi.org/10.1155/2017/6924601 |
| work_keys_str_mv | AT abdulkarim ranitidineloadedbiopolymerfloatsdesigningcharacterizationandevaluation AT muhammadashrafshaheen ranitidineloadedbiopolymerfloatsdesigningcharacterizationandevaluation AT tahirmehmood ranitidineloadedbiopolymerfloatsdesigningcharacterizationandevaluation AT abdulraufraza ranitidineloadedbiopolymerfloatsdesigningcharacterizationandevaluation AT musadiqaziz ranitidineloadedbiopolymerfloatsdesigningcharacterizationandevaluation AT badardin ranitidineloadedbiopolymerfloatsdesigningcharacterizationandevaluation |