Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing
Cell membrane-derived nanovesicles (NVs) have emerged as promising alternatives to extracellular vesicles (EVs) for wound healing applications, addressing the limitations of traditional EVs, which include insufficient targeting capability, low production yield, and limited drug-loading capacity. Thr...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642500153X |
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| author | Wenwen Li Huihui Zhang Lianglong Chen Chaoyang Huang Ziwei Jiang Hai Zhou Xinxi Zhu Xiaoyang Liu Zesen Zheng Qiuyi Yu Yufang He Yanbin Gao Jun Ma Lei Yang |
| author_facet | Wenwen Li Huihui Zhang Lianglong Chen Chaoyang Huang Ziwei Jiang Hai Zhou Xinxi Zhu Xiaoyang Liu Zesen Zheng Qiuyi Yu Yufang He Yanbin Gao Jun Ma Lei Yang |
| author_sort | Wenwen Li |
| collection | DOAJ |
| description | Cell membrane-derived nanovesicles (NVs) have emerged as promising alternatives to extracellular vesicles (EVs) for wound healing applications, addressing the limitations of traditional EVs, which include insufficient targeting capability, low production yield, and limited drug-loading capacity. Through mechanical cell extrusion methods, NVs exhibit superior characteristics, demonstrating enhanced yield, stability, and purity compared to natural EVs. These NVs can be derived from various membrane sources, including single cell types (stem cells, blood cells, immune cells, and bacterial membranes), hybrid cell membranes and cell membranes mixed with liposomes, with each offering unique therapeutic properties. The integration of genetic engineering and surface modifications has further enhanced NV functionality, enabling precise targeting and improved drug delivery capabilities. Recent advances in NV-based therapies have demonstrated their potential across multiple biomedical applications. Although challenges persist in terms of standardization, storage stability, and clinical translation, the combination of natural cell-derived functions with artificial modification potential positions NVs as a promising platform for next-generation therapeutic delivery systems, thereby offering new possibilities in wound healing applications. Finally, we explore the challenges and future prospects of translating NV-based therapeutics into clinical practice, providing insights into the future development of this innovative approach in wound healing and tissue repair. |
| format | Article |
| id | doaj-art-666b339cb07d44aa92fcc829976a2e3e |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-666b339cb07d44aa92fcc829976a2e3e2025-08-20T02:45:56ZengElsevierMaterials Today Bio2590-00642025-04-013110159510.1016/j.mtbio.2025.101595Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healingWenwen Li0Huihui Zhang1Lianglong Chen2Chaoyang Huang3Ziwei Jiang4Hai Zhou5Xinxi Zhu6Xiaoyang Liu7Zesen Zheng8Qiuyi Yu9Yufang He10Yanbin Gao11Jun Ma12Lei Yang13Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaCorresponding author.; Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaCorresponding author.; Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaCorresponding author.; Department of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, ChinaCell membrane-derived nanovesicles (NVs) have emerged as promising alternatives to extracellular vesicles (EVs) for wound healing applications, addressing the limitations of traditional EVs, which include insufficient targeting capability, low production yield, and limited drug-loading capacity. Through mechanical cell extrusion methods, NVs exhibit superior characteristics, demonstrating enhanced yield, stability, and purity compared to natural EVs. These NVs can be derived from various membrane sources, including single cell types (stem cells, blood cells, immune cells, and bacterial membranes), hybrid cell membranes and cell membranes mixed with liposomes, with each offering unique therapeutic properties. The integration of genetic engineering and surface modifications has further enhanced NV functionality, enabling precise targeting and improved drug delivery capabilities. Recent advances in NV-based therapies have demonstrated their potential across multiple biomedical applications. Although challenges persist in terms of standardization, storage stability, and clinical translation, the combination of natural cell-derived functions with artificial modification potential positions NVs as a promising platform for next-generation therapeutic delivery systems, thereby offering new possibilities in wound healing applications. Finally, we explore the challenges and future prospects of translating NV-based therapeutics into clinical practice, providing insights into the future development of this innovative approach in wound healing and tissue repair.http://www.sciencedirect.com/science/article/pii/S259000642500153XCell membrane-derived nanovesiclesExtracellular vesiclesWound healingBionanotechnologyBiomimetic materials |
| spellingShingle | Wenwen Li Huihui Zhang Lianglong Chen Chaoyang Huang Ziwei Jiang Hai Zhou Xinxi Zhu Xiaoyang Liu Zesen Zheng Qiuyi Yu Yufang He Yanbin Gao Jun Ma Lei Yang Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing Materials Today Bio Cell membrane-derived nanovesicles Extracellular vesicles Wound healing Bionanotechnology Biomimetic materials |
| title | Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing |
| title_full | Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing |
| title_fullStr | Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing |
| title_full_unstemmed | Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing |
| title_short | Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing |
| title_sort | cell membrane derived nanovesicles as extracellular vesicle mimetics in wound healing |
| topic | Cell membrane-derived nanovesicles Extracellular vesicles Wound healing Bionanotechnology Biomimetic materials |
| url | http://www.sciencedirect.com/science/article/pii/S259000642500153X |
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