Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington’s disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition

Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington’s disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition

Abstract Background Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor decline and neuronal loss, with no curative disease-modifying therapies available. The mitochondrial toxin 3-nitropropionic acid (3-NP) is widely used to model HD-like pathologies....

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Bibliographic Details
Main Authors: Ayooluwa Gabriel Ibiayo, Peeraporn Varinthra, Mukundan Nagarajan, Ingrid Y Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Medicine
Subjects:
Coniferaldehyde
Huntington’s disease
JAK2/STAT3 signaling
PKM2
Oxidative stress
Neuroinflammation
Online Access:https://doi.org/10.1186/s10020-025-01308-0
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